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Duke & Cryo-Cell plan big clinic for unproven infusions of kids

June 9, 2021 August 26, 2022 / By Professor Paul Knoepfler, Ph.D. / 6 Comments

Professor Joanne Kurtzberg’s clinical work at the Duke Autism Center on umbilical cord blood for autism and cerebral palsy (CP) involves a partnership with a publicly-traded cord blood banking firm called Cryo-Cell. Kurtzberg is also the Medical Director at the firm. In addition they have intellectual property in this area. The Duke team’s efforts, including …

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Cord conflicts at the journal Stem Cells Translational Medicine

May 20, 2021 May 25, 2021 / By Professor Paul Knoepfler, Ph.D. / 9 Comments

The journal Stem Cells Translational Medicine has a long track record of publishing great work. I also have a lot of respect for the editors there and I’ve published there myself. But a few recent events have sparked concerns including over possible undisclosed conflicts of interest in some papers there about cord blood for autism. …

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Duke Autism Center has Panama clinic to thank for $10s millions?

October 13, 2020 December 12, 2022 / By Professor Paul Knoepfler, Ph.D. / 10 Comments

Drs.-Neil-Riordan-and-Joanne-Kurtzberg-MSCs-for-autism

What do a Panama stem cell clinic and the Duke Autism Center have in common? More than I might have imagined. It’s a remarkable story that needs telling. Duke Autism Center There is a puzzle when it comes to the controversial idea of using cord blood for autism. Why? Because two of the strongest proponents …

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Mesoblast MSCs Quell Peds GvHD; On Road to FDA Approval?

August 20, 2020 June 8, 2022 / By Ricki Lewis / 6 Comments

MSCs-mesenchymal-stem-cells-stromal-cells-small

Graft-versus-host disease (GVHD) is counterintuitive In the weeks and months following a transplant, a major concern is the recipient’s immune system rejecting the “foreign” biological material. But in GVHD, the opposite happens: transplanted tissue unleashes a horde of T cells that spark a cascade of inflammation, within 100 days. Typically, GVHD follows a bone marrow …

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BARDA drops funding of research into stem cells for COVID-19

June 29, 2020 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 14 Comments

Katie Thomas at the New York Times reports that BARDA has dropped considering funding applications for stem cells for COVID-19. The move is part of a larger shift in funding priorities away from lung treatments and toward vaccine development. The decision has puzzled and even angered some stem cell firms and researchers. BARDA stands for …

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Duke Autism Center trial: no benefit of cord blood for autism

May 20, 2020 August 26, 2022 / By Professor Paul Knoepfler, Ph.D. / 12 Comments

A solid new, blinded placebo-controlled Phase II study from the Duke Autism Center clearly shows no benefit of cord blood for autism. Surprisingly, the team has said they are encouraged by the results. As a result, they apparently will continue this kind of work anyway despite their data. In contrast, I see the data as a …

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Stem cells for autism: time to hit pause in 2018?

October 22, 2018 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 9 Comments

Stem cells for autism? After watching this area for many years, I’m not sure there’s any “there there”. There are logical reasons to think that certain stem cells might help many specific diseases, but in my view autism isn’t likely to be one of them. I hope I’m wrong, but today at least in 2018, …

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Cord blood for cerebral palsy: mostly discouraging new trial data

October 31, 2017 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 6 Comments

umbilical-cord-blood, umbilical cord blood stem cells

Some notable newly published Phase II data from the Duke cord blood for cerebral palsy trial unfortunately doesn’t give much reason for optimism that this approach is going to have a substantial positive effect for these kids. The double-blinded, placebo-controlled study did not find a meaningful benefit overall from infusions of autologous cord blood (ACB) for …

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Why I am still very skeptical about stem cells for autism

September 10, 2017 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 26 Comments

When patient families reach out to me, one of the most common questions is whether stem cells for autism offer real hope. The short answer at this time remains “no”. Of course, it’s not as simple as just “no” because there isn’t enough data to be sure, but there is reason for major skepticism about …

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