When I was first really getting into stem cells as a trainee the name Catherine Verfaillie came up as a scientist to watch in the adult stem cell area. It wasn’t too long after that though that I started hearing that some of the work from her lab at the University of Minnesota was being […]
Recommended reads: Nature Catherine Verfaillie retraction, Horvath paper, Vertex Read More »
As we think about how much of a role belief should play in the hard sciences such as cell biology, a supposed cell type called VSEL or very-small embryonic stem cell-like cells comes to mind. For these guys it seems to me that the ratio of data to belief isn’t great. VSELs have nine lives. I
The role of belief in hard science: the VSEL case Read More »
Dr. Paolo Macchiarini exemplifies how things can change quickly in the stem cell world and go from sky highs to deep lows. Stem cell rollercoasters Over the years, a few academic stem cell researchers as well as some operators in the unproven clinic sphere have had dizzying ups and downs. There’s John Kosolcharoen. His company
Paolo Macchiarini guilty in criminal stem cell case but does a Houdini again Read More »
Eight years ago two new Nature papers broke on the scene reporting supposed STAP cells with one of the senior authors, Charles Vacanti of Harvard, most well known previously for making the so-called “Vacanti mouse” along with his brother Joseph. The Vacanti mouse had a bioengineered human ear growing on its back. While STAP cells
Recommended reads: Dux, 3D printed ear brings Vacanti mouse to mind, AMD, more Read More »
When I read about Elizabeth Holmes and her blood testing startup Theranos I see parallels to hucksters in the arena of stem cells and cell therapy. I’m thinking especially of the unproven stem cell clinics out there. It goes farther than that though too, including people who aren’t hucksters at all but get caught up
Elizabeth Holmes, Theranos, & lessons for the stem cell field Read More »
The Niche has had many authors over the years, focusing on expertise in the biomedical arena and in particular related to stem cells. I’ve invited many authorities in particular areas to write posts. Over the years I’ve written probably 99+% of the posts here on The Niche, but we’ve also had some great guest authors
Authors on The Niche Read More »
When I was a kid there was this commercial on TV for Chiffon margarine (fake butter) with the slogan, “It’s not nice to fool mother nature!” As a kid I thought it was dumb but kind of funny. A modified version of that mother nature advertising slogan has become a cultural tagline. Don’t mess with
Don’t mess with (mother) Nature: why risk taking on a powerhouse journal? Read More »
Could He Jiankui have faked part or all of his CRISPR babies story? If so, how? Why? Or to put it another way, almost everyone seems to be assuming the story is real, but should we be more skeptical? Should we flip things around and assume the story isn’t entirely kosher until proven otherwise? I once
History tells us to be more skeptical of He Jiankui’s CRISPR baby story Read More »
A researcher working at Kyoto University has reportedly engaged in misconduct leading to an institutional request for retraction of a paper from the journal Stem Cell Reports. The paper in question appears to have rather large-scale problems: “Kohei Yamamizu, a specially appointed assistant professor at the university’s Center for iPS Cell Research and Application, falsified all
Perspectives on high-profile stem cell retraction in the making from Kyoto University Read More »
Does the new gene editing method NgAgo work or not? If not, what happened? The answers to both questions seem to depend on who you ask and what you read. As much as CRISPR has been the revolutionary in the genetic modification technology arena over past methods, could CRISPR itself in the next few years
Controversy over CRISPR challenger NgAgo irreproducibility reported Read More »