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Countering that Pro-Heritable Human CRISPR WSJ Piece

October 22, 2017 / Professor Paul Knoepfler, Ph.D. / 9 Comments

It’s germline, heritable human CRISPR time, right? Wrong. But the particularly enthusiastic supporters of heritable human CRISPR often cite hypothetical benefits in glowing terms, but either don’t mention risks or strongly downplay them. These fans also tend to leave alternative, proven and safe technologies such as preimplantation genetic diagnosis (PGD) out of the discussion or […]

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Ask Me Anything (AMA)

September 21, 2017 / Professor Paul Knoepfler, Ph.D.

Inspired by the Reddit AMAs (Ask Me Anything) that I’ve done over the past few years, I’m launching this new page (new as of September 2017) where I invited readers of this blog to ask me questions. The questions can be about stem cells, CRISPR, brain cancer research, other science topics, about my lab’s research,

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1st Knockout Human Embryos Made with CRISPR: My Take on the Pub

September 20, 2017 / Professor Paul Knoepfler, Ph.D. / 4 Comments

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Scientist make knockout human embryos with CRISPR? Today we see a new Nature paper (Fogarty, et al.) on CRISPR “gene editing” of human embryos, this time from the UK from Kathy Niakan’s group. Niakan got UK permission about 18 months ago to CRISPR healthy human embryos so they’ve been hard at work since. Because Fredrik

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Scientist’s dilemma: find a public voice on big issues or stay silent?

August 22, 2017 / Professor Paul Knoepfler, Ph.D. / 1 Comment

There is a scientist’s dilemma: should you speak out on important, sometimes controversial issues in science, where you not only can potentially have positive impact, but also risk being attacked for it? Or do you remain silent? I’ve now been blogging for more than 7 years. I’ve battled the often exploitive for-profit stem cell clinics

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Young blood as anti-aging fountain of youth: hype or hope?

August 20, 2017 / Professor Paul Knoepfler, Ph.D. / 9 Comments

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There’s an idea floating around out there called “young blood” to use donations from young folks to infuse older people to reverse aging. I’m skeptical. Imagine an old man and a teenager sitting side by side, with blood flowing from the kid to the oldster in a stab at anti-aging. Sort of like a one-way

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Senate Passes Federal Right-To-Try: Poll on Your Opinion

August 4, 2017 / Professor Paul Knoepfler, Ph.D. / 4 Comments

The U.S. Senate just passed a bill that if it becomes law would codify Right-To-Try as a federal law, meaning terminally patients across the U.S. could ask their physicians and drug manufacturers to be given still investigational therapies such as still unproven stem cell therapies in development. The bill’s official name is “The Trickett Wendler

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Upcoming Right-To-Try debate: NYU’s Roxland and Goldwater’s Sandefur

July 20, 2017 / Professor Paul Knoepfler, Ph.D. / 3 Comments

Should patients have the Right To Try experimental therapies that could be unsafe and ineffective? What if those patients have a terminal illness and no reasonable prospects of being helpful to conventional medicine? Doesn’t it make perfect sense to let them try a risky approach if they want to do so? On the other hand,

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Privacy Policy

July 18, 2017 / Professor Paul Knoepfler, Ph.D.

Privacy Notice (note for comment policy scroll down) This privacy notice discloses the privacy practices for The Niche at https://ipscell.com. This privacy notice applies solely to information collected by this website. It will notify you of the following: What personally identifiable information is collected from you through the website, how it is used and with

Reading the tea leaves as new FDA commish Gottlieb blogs on regenerative medicine

July 11, 2017 / Professor Paul Knoepfler, Ph.D. / 3 Comments

New FDA Commissioner Dr. Scott Gottlieb, M.D., has in the past touched on stem cells and regenerative medicine therapies in speeches or written comments prior to starting his tenure at the agency. Now that he is Commissioner, he is poised to have direct impact on our field rather quickly and potentially with major changes in

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The Niche’s 2,000th post: where do we go from here?

July 6, 2017 / Professor Paul Knoepfler, Ph.D. / 5 Comments

2,000 is a big number. As of this week I’ve now published 2,000 posts here on The Niche since I started back in early 2010. I can’t quite believe it myself. To celebrate that milestone, I have revamped The Niche in terms of its organization and style with the help of a very skilled web

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