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Weekly reads: FDA modernization, TFs on the brain, mortality timer, pluripotent trials

January 19, 2025 / Professor Paul Knoepfler, Ph.D. / 1 Comment

How will things change at the FDA under the second Trump Administration? It’s a key question for our field but not easy to answer. Most likely there will be more instability at the agency. Some leaders, like of CDER, have already left. in my overall regenerative medicine predictions for 2025, I’ve included more predictions about […]

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Perspectives as Charles Brenner challenges David Sinclair on longevity claims

January 7, 2025 / Professor Paul Knoepfler, Ph.D. / 2 Comments

Professor Charles Brenner of City of Hope does great research, but I also applaud his efforts against longevity hype. Recently, Brenner and James Timmons publicly questioned some of the work of Harvard Professor David Sinclair. It’s a notable case of academics intensely disagreeing in the public space. Background While it’s interesting, it’s also a somewhat

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Weekly stem cell reads: HSCT, old embryo models, aging stem cells

December 15, 2024 / Professor Paul Knoepfler, Ph.D. / 3 Comments

What is a stem cell therapy? Does it have to include stem cells put into the body? Would you include a therapy that uses differentiated cells made from stem cells? I generally do use the term in that broader way. A similar question comes to mind: what is regenerative medicine? Should it include both cell

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Refreshing WSJ piece on longevity ‘guru’ David Sinclair

December 10, 2024 / Professor Paul Knoepfler, Ph.D. / 3 Comments

I’ve written before about concerns related to longevity research hype from Harvard professor David Sinclair. The media often eats up statements about longevity from Sinclair and a few other scientists in that space. There is also endless coverage of the latest exploits of wealthy health influencer Bryan Johnson. For that reason it was refreshing to

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Joe Rogan shows more love for unproven stem cells despite risks

October 23, 2024 / Professor Paul Knoepfler, Ph.D. / 12 Comments

Cellular Performance Institute, CPI Tijuana

Joe Rogan just keeps glowing about clinics offering unproven stem cells like most recently the Cellular Performance Institute in Tijuana. Often Joe talks about his own experiences getting stem cells, but other times he refers anecdotally to others who supposedly had great experiences. While it’s not unusual for some celebrities to get stem cells at

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Stanford’s Mike Snyder and wellness coach Tony Robbins together yield some puzzling research

September 25, 2024 / Professor Paul Knoepfler, Ph.D. / 3 Comments

Mike Snyder and Tony Robbins, Stanford Tony Robbins

What do you think of when I mention Stanford professor Mike Snyder and self-help guru Tony Robbins together? I would not necessarily have imagined them forming a connection but science is full of surprises. I’ve admired Snyder’s work in genetics for a long time. I’m most familiar these days with Robbins for his interest in

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FDA warns Mother Stem Institute & Alvaro Skupin

September 10, 2024 / Professor Paul Knoepfler, Ph.D. / 2 Comments

The FDA just warned a Florida stem cell clinic firm called Mother Stem Institute run by Dr. Alvaro Skupin. Background: Mother Stem Institute past issues I’ve written about this clinic and Dr. Skupin in the last few years. Just about a year ago I blogged the news that a patient suit against the clinic was

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Six possible natural stem cell boosts

September 4, 2024 / Professor Paul Knoepfler, Ph.D. / 11 Comments

What might be some natural stem cell boosts? Should we be skeptical of such an idea? Boosting stem cells naturally Data suggests there could be ways to boost our stem cells naturally but it’s still early days in this line of research. How do we define a “stem cell boost”? I think of it as

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Media like the AP promote unproven stem cell clinics such as R3 Stem Cell

August 21, 2024 / Professor Paul Knoepfler, Ph.D. / 8 Comments

Some of you might remember the stem cell clinic firm R3 Stem Cell. I have major concerns about some of what they are marketing including in the U.S. I was reminded of R3 Stem Cell again just now. The Associated Press (AP) ran a PR on R3 Stem like it was a news story. I

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Weekly stem cell reads: AI-human hybrids, eye drops, Cell Surgical Network case delay

August 18, 2024 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

Before we jump into our weekly stem cell and regenerative medicine reads, check out my new video on our stem cell YouTube channel below on robots with human brain tissue. In that video, I discuss the integration of computers and other technologies into the human body. When involving the brain, these technologies are often called

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