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Mesoblast MSCs Quell Peds GvHD; On Road to FDA Approval?

August 20, 2020 / Ricki Lewis / 6 Comments

MSCs-mesenchymal-stem-cells-stromal-cells-small

Graft-versus-host disease (GVHD) is counterintuitive In the weeks and months following a transplant, a major concern is the recipient’s immune system rejecting the “foreign” biological material. But in GVHD, the opposite happens: transplanted tissue unleashes a horde of T cells that spark a cascade of inflammation, within 100 days. Typically, GVHD follows a bone marrow […]

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Weekly reads: organoids, COVID-19, CIRM & cool new pubs

June 28, 2020 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

Human-intestinal-organoids-infected-with-SARS-CoV-2-white.-Credit-Joep-BeumerClevers-groupHubrecht-Institute

Organoids are providing a novel avenue into the pathogenesis of COVID-19 and novel models for drug screening. A number of new preprints on respiratory organoids shed new light in this area. They were highlighted in a Nature newsy piece, Mini organs reveal how the coronavirus ravages the body. It’s a challenge to study COVID-19 infections because just infecting

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ViaCyte Q&A: CRISPR Tx quick progress, ongoing diabetes trial, & more

September 25, 2019 / Professor Paul Knoepfler, Ph.D. / 9 Comments

ViaCyte is one of the most exciting stem cell and regenerative medicine biotech companies so I like to try to check in with them regularly. Today’s post is my new interview with ViaCyte leader Paul Laikind on recent developments. We had a great chat about the science and how things are looking upbeat for the

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History tells us to be more skeptical of He Jiankui’s CRISPR baby story

December 9, 2018 / Professor Paul Knoepfler, Ph.D. / 2 Comments

Could He Jiankui have faked part or all of his CRISPR babies story? If so, how? Why? Or to put it another way, almost everyone seems to be assuming the story is real, but should we be more skeptical? Should we flip things around and assume the story isn’t entirely kosher until proven otherwise? I once

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Hope on Parkinson’s front: Japan IPSC trial 1st patient

November 18, 2018 / Professor Paul Knoepfler, Ph.D. / 2 Comments

Fig-3i-Kikuchi-et-al.-Nature-2017-IPS-cell-Parkinsons-

In Parkinson’s Disease patients develop neurological dysfunction as they lose a special kind of brain cell called dopaminergic (or dopamine) neurons. While a number of different approaches to this disease have been studied for decades, nothing has proven particularly successful in slowing its progression. As a result there has been a big need for novel thinking

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Poll on refunding CIRM on eve of informational legislative hearing

August 14, 2018 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Our California stem cell agency, CIRM, started as a baby even before I came to California in 2006 to start my lab here at UC Davis School of Medicine, but now CIRM or to use its full name the California Institute for Regenerative Medicine is I’d say a full-grown, mature adult at about age 13

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Lorenz Studer on Day 1 #ISSCR2018: HESC-based therapies for Parkinson’s Disease

June 20, 2018 / Professor Paul Knoepfler, Ph.D. / 2 Comments

One of the highlights of Day 1 of #ISSCR2018 for me so far was the talk by Lorenz Studer (Co-Founder of BlueRock) on the use of human embryonic stem cell (HESC)-derived dopamine neurons for Parkinson’s Disease. Note that for this post and if I have time any others on this meeting, they are probably going

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Ian Wilmut, who cloned Dolly, opens up about his Parkinson’s Disease

April 11, 2018 / Professor Paul Knoepfler, Ph.D. / 3 Comments

One of the most famous living biological scientists, Sir Ian Wilmut, just announced that he has Parkinson’s Disease. I wish him the best in dealing with this illness. Wilmut is very well-known for having cloned the first mammal, Dolly the Sheep. This work followed on the earlier breakthrough by Sir John Gurdon of cloning the

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Just one word placentas: Can Celularity live up to hype?

February 20, 2018 / Professor Paul Knoepfler, Ph.D. / 5 Comments

I’ve been blogging about stem cells now for about 8 years and the recent level of hype about and fluffy media coverage of Celularity, the biotech spun out of Celgene, ranks right up here with the most extreme past cases I’ve seen. What is Celularity and who is its leadership? It’s a new biotech focused

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On President’s Day: Dealing with Reality Trump is Threat to Science & Democracy

February 19, 2018 / Professor Paul Knoepfler, Ph.D. / 8 Comments

On President’s Day, let’s think about our country’s leader, Donald Trump. Do we have to? Yeah, sometimes we do. For the first time in my lifetime, I see the President of the United States as a serious threat to overall science & to our country’s democracy. Trump is not well-acquainted with fact-based reality and that’s

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