Below is a conversation with bioethics commentator Kelly Hills (who BTW has a great blog), tackling some of the key issues surrounding the potential use of CRISPR-Cas9 technology to make heritable human genetic modification. I really appreciate her clear and insightful answers to some tough questions that many are grappling with today on this topic. Part […]
Kelly Hills interview: human genetic modification & bioethics Read More »
I invited the Chief Scientific Officer (CSO) of Bioheart, Kristin Comella, to do an interview after hearing some buzz that this could be a critical time for the company and that it might have been recently visited by the FDA. Note that Comella not just Bioheart CSO, but also the primary instructor for physician training in stem
Interview with Bioheart CSO, Kristin Comella including on FDA Read More »
Remember that old TV show the Odd Couple with very proper Felix Unger and his polar opposite Oscar Madison who has all kinds of baggage? They’ve cloned it into a remake to be on TV soon here in the US in 2015. It seems only fitting then that actual human cloning research has a new
The Odd Couple of Cloning Research: Mitalipov & Woo Suk Hwang Unite Read More »
Dear UK Parliament and Science and Technology Committee, I am writing to you about your deliberations on “mitochondrial donation” (also known as 3-parent technology) intended for the purpose of preventing heritable mitochondrial disorders. I am concerned about the Department of Health’s recent draft regulations that would allow 3-parent experiments to go forward and the possibility that the UK
Open letter to UK Parliament: avoid historic mistake on rushing 3-parent technology Read More »
Sperm and brain tumors? Sometimes in science there are unexpected threads tying seemingly very different things together. Unraveling the knots in these threads can lead to new insights into important developmental processes and mechanisms of disease. My lab studies epigenomic and transcription factors including a molecule called histone variant H3.3 (more here on H3.3). H3.3
What is the connection between sperm and brain tumors? Read More »
This is a crowdsource page for people who want to post their findings on their attempts to validate the STAP stem cell ( ＳＴＡＰ細胞) method. I’m going to color successful or even moderately encouraging reports green and failures/discouraging results in red. *For those with longer attention spans, see some additional important considerations for this crowdsourcing effort at
Today’s post is an interview I did with Dr. Van Bokkelen covering 10 questions. Dr. Gil Van Bokkelen is Chairman and CEO of Athersys, Inc., a company that has focused heavily on stem cells and regenerative medicine for more than a decade. For more on Dr. Van Bokkelen’s background see additional bio section at the end of
Interview with Gil Van Bokkelen of Athersys Read More »
Yesterday’s report of human therapeutic cloning to make embryonic stem (ES) cell lines is a big deal. I support the work and I believe it is very important. People’s reactions to it vary wildly depending on their agendas of course. This post is a no-nonsense overview of the main points. My overall point. This is
5 human therapeutic cloning talking points dissected Read More »
Why aren’t there are super pygmy vertebrates? For most vertebrate animals, their early embryonic development unfolds in extremely congruent fashions. Embryo growth is stem cell-dependent and in large part, despite different gestational periods, the molecular and cellular machinery that controls vertebrate development is almost perfectly conserved. Yet at maturity vertebrates end up with a range
Why aren’t there vertebrate super pygmies? Read More »
Why do people have such a big brain compared to other animals? Vertebrate embryonic development is a highly conserved process, particularly in the earliest phases. (note: you may find this September 2020 post on regulation of bee brain size to be interesting.) A wide variety of vertebrate animals including humans start out with embryonic body plans
Why is the human brain super-sized? Read More »