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Autologous or Allogeneic: a stem cell question (guest post from Jeanne Loring)

January 19, 2019 / Professor Paul Knoepfler, Ph.D. / 20 Comments

stem-cells-and-development-parkinsons-disease

By Jeanne Loring What can you do with cells that live forever and can make every cell type in the body? The answer is: remarkable things, as new reports of clinical trials using cell types derived from pluripotent stem cells indicate. Pluripotent stem cells are either derived from embryos donated from IVF procedures (human embryonic […]

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20 stem cell & regenerative medicine predictions for 2019

January 2, 2019 / Professor Paul Knoepfler, Ph.D. / 6 Comments

For a long time at the end of each year, I’ve been making stem cell predictions for the coming year. Most often I’ve been making a “top 20” list of predictions and today’s post has my list for 2019. You can see how I did for 2018 here, which might have been my best year

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Good final grades on my 20 x 2018 stem cell predictions

December 26, 2018 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Each year I make a list of stem cell predictions for the following year and I’ll release my predictions for 2019 soon, but first I’m grading how my 20 predictions for 2018 turned out. It seems I did better than usual predicting what would happen this year. I only got a couple partial credit or

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Papers on artificial embryos and muscle stem cells

October 7, 2018 / Professor Paul Knoepfler, Ph.D. / 1 Comment

If you are sick of the general news lately, I recommend turning to the wonder of cool science like the thought-provoking data in the duo of new stem cell pubs discussed below including on artificial embryos. Synthetic embryos A team led by Alfonso Martinez-Arias reports new findings in their Nature letter in the growing area

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News bites: CIRM, anti-MSCs, & human eggs from stem cells

September 30, 2018 / Professor Paul Knoepfler, Ph.D. / 8 Comments

Stem cells are always in the news so what’s up in the last week or two? CIRM News The dialogue over CIRM’s future is picking up a bit of steam. The San Francisco Chronicle did an in-depth piece on CIRM some weeks back and then opined that they didn’t feel supportive of another round of

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Stem cell news bites: Astellas trial, cystic fibrosis claim, a few cool papers

August 7, 2018 / Professor Paul Knoepfler, Ph.D. / 5 Comments

Stem cell news is always burbling up, sometimes right there in front of us on the web and other times via networks of people. Astellas news. Some may remember there used to be this pioneering stem cell biotech called ACT, which then became Ocata, and finally was acquired by the big company Astellas. One of

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TGIF weekend reads: senolytics, new CRISPR, stem cells, & 3 wacky things

July 13, 2018 / Professor Paul Knoepfler, Ph.D.

Over the weekends I try to catch up on more diverse reading and sometimes come up with a list of stuff I want to get to during this time, but I also put together weekend reads usually on Fridays as a kind of TGIF on The Niche for the wider audience here. So here’s the

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Midterm grades on my 20 x 2018 stem cell predictions

June 27, 2018 / Professor Paul Knoepfler, Ph.D. / 3 Comments

Every year in December I go out onto a limb and make stem cell predictions for the coming year as I did in late 2017 for this year. Then usually around the 1/2-way point through the year I check in on how the predictions are faring so far at that point. In this post I give

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Possible safety concerns from new stem cell, RPE vision loss study report

June 10, 2018 / Professor Paul Knoepfler, Ph.D. / 2 Comments

Figure-1-Mehat-et-al.-AAO-Journal-2018-810x1024-1

With stem cells for vision loss, first we want to be sure a treatment won’t make things worse. Several teams around the globe are rigorously studying stem cell-based approaches to vision loss via regulatory-compliant studies including for macular degeneration with some results cautiously upbeat on safety from early phase analyses, but data from a new study on

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Perspectives on new stem cells for vision loss paper

April 8, 2018 / Professor Paul Knoepfler, Ph.D. / 11 Comments

F2-Kashani-et-al.-Stem-cells-for-vision-loss

Do stem cells for vision loss offer real hope? I believe so, but it’s a long road and must be done right. A new paper in this area generated some buzz on top of an earlier recent pub (mentioned in this post) just a week or so ago about the potential of stem cells for vision

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