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Masayo Takahashi (高橋政代) on IPSC Trial for Vision

July 7, 2015 / Professor Paul Knoepfler, Ph.D. / 9 Comments

Masayo Takahashi (高橋政代) on IPSC Trial for Macular Degeneration By Michael Cea Stem Cell Analyst & Advocate (editor’s note: piece was originally posted on Michael’s blog here; follow Michael on Twitter @msemporda) Masayo Takahashi interview Having followed closely the developments in programs using pluripotent based therapeutics I was fortunate during ISSCR2015 to have the opportunity to […]

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Landmark IPSC clinical study on hold due to genomic issue

July 1, 2015 / Professor Paul Knoepfler, Ph.D. / 42 Comments

The pioneering induced pluripotent stem cell (IPSC) clinical study in Japan led by top stem cell clinical researcher Dr. Masayo Takahashi has been stopped reports the WSJ in Japan. This development is confirmed by other sources and in a PDF report by RIKEN (in Japanese here). One patient was transplanted in September 2014 with their own IPSC-derived

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How are my 20 stem cell predictions for 2015 doing?

June 30, 2015 / Professor Paul Knoepfler, Ph.D. / 9 Comments

Each year towards the end of December I make predictions for the coming year as I did for 2015. In the past I usually make a top 10 prediction list, but for this year I made 20 predictions. Admittedly some of them may have been more hopes than predictions. At mid-year today on June 30th,

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Monday morning musings: stocks, ISSCR, grants, CRISPR, New Book

June 29, 2015 / Professor Paul Knoepfler, Ph.D. / 5 Comments

What’s on your mind on this Monday morning and are you caffeinated enough yet? Depending on where you live it may even be time for dinner, bed, or already early Tuesday. Here are some Monday musings… To get safe and effective stem cell treatments to patients in a responsible, compliant manner you need commercial efforts

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Sally Temple on adult RPEs for vision impairment, IND, & more

June 17, 2015 / Professor Paul Knoepfler, Ph.D. / 4 Comments

At the recent RPI stem cell and bioengineering meeting, the Neural Stem Cell Institute’s Sally Temple talked about her group’s intriguing retinal pigmented epithelial cell (RPE) research. With the broad focus of attention in the world of RPEs mostly on those derived from either human ESC or IPSC, it was exciting to here about the

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Post-Publication Paper Reviews & Commentaries

January 2, 2015 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

2015 Review of Vogelstein “Bad Luck” Cancer & Stem Cell Paper in Science January 02, 2015 2014 What Does New Paper Mean for Future of Nuclear Transfer ES Cells? November 9, 2014 Encouraging New Paper on ACT Stem Cell-Based Trial for Macular Degeneration October 14, 2014 Top 10 Takeaways From Harvard Stem Cell Diabetes

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Stem Cell Person of the Year 2014: Masayo Takahashi (高橋政代)

November 4, 2014 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Congratulations to Masayo Takahashi (高橋政代), MD, PhD, the winner of the 2014 Stem Cell Person of the Year Award. Dr. Takahashi received this award including the $2,000 prize for her exceptional achievements in stem cell research in 2014. She was selected as the winner from a stellar group of top 12 finalists this year. Takahashi leads

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Shinya Yamanaka Interview on Clinical Use of IPSC

October 21, 2014 / Professor Paul Knoepfler, Ph.D. / 10 Comments

I invited Nobel Laureate Shinya Yamanaka to do an interview on the future of clinical translation of induced pluripotent stem cells (iPSC). He provides some intriguing new insights into the iPSC field and the broader stem cell arena. PK: The Takahashi Team’s active Clinical Study using iPSCs to make RPEs to treat Macular Degeneration has

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BioTime Cell Cure Files IND with FDA for ES cell AMD therapy

October 6, 2014 / Professor Paul Knoepfler, Ph.D. / 2 Comments

Stem cell biotech BioTime announced the news today that its subsidiary Cell Cure Neurosciences (Cell Cure) has filed an IND with the FDA for an embryonic stem (ES) cell-based therapy for Dry age-related macular degeneration (AMD). The product to be tested is OpRegen, which the company indicates is “the first IND for an ES cell-based

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Landmark: patient receives first ever iPS cell based transplant

September 12, 2014 / Professor Paul Knoepfler, Ph.D. / 10 Comments

In a major first for the stem cell and regenerative medicine fields, a patient in Japan today received a pioneering transplant of a retinal pigmented epithelial (RPE) sheet made from induced pluripotent stem (iPS) cells, also known by the acronym IPSC. This is the first ever iPS cell-based transplant into a human. The patient is

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