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IPS cell field update: easy culture, Parkinson’s, scarring, immune cells, & mutations

January 12, 2020 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Fibrosis-model-IPS-cells-Fig-1b-Vijayaraj-et-al-Cell-Reports-2019

Where do things stand today in 2020 with IPS cell research? It’s been 14 years since they were first reported, but they continue to make news. Back in 2006 I was wrapping up my postdoc with Bob Eisenman at The Hutch in Seattle, largely studying Myc, when Shinya Yamanaka published his first induced pluripotent stem […]

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Japan stem cell clinical studies rapidly piling up

March 17, 2019 / Professor Paul Knoepfler, Ph.D. / 5 Comments

Shibata-et-al.-Cell-reports-2018-corneal-structures-made-from-hIPSCs

Japan is a leader in stem cell and regenerative medicine research, and in particular in clinical translation toward the bedside. Induced pluripotent stem cell (IPSC)-based investigational therapies are rightly an area of focus in Japan given their invention by Nobel Laureate Shinya Yamanaka. Small clinical studies based on IPSC have been initiated there for several

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50 stem cell influencers on Twitter to follow in 2019

February 25, 2019 / Professor Paul Knoepfler, Ph.D.

stem cells on Twitter, top-stem-cell-influencers-Twitter

Who are the top stem cell and regenerative medicine influencers to follow on Twitter and elsewhere in 2019? Terrapin asked this kind of broad question to some within our community about 5 years ago and came up with a Top 50 list of stem cell influencers, which I like to joke I was “at the top

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Autologous or Allogeneic: a stem cell question (guest post from Jeanne Loring)

January 19, 2019 / Professor Paul Knoepfler, Ph.D. / 20 Comments

stem-cells-and-development-parkinsons-disease

By Jeanne Loring What can you do with cells that live forever and can make every cell type in the body? The answer is: remarkable things, as new reports of clinical trials using cell types derived from pluripotent stem cells indicate. Pluripotent stem cells are either derived from embryos donated from IVF procedures (human embryonic

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Stem cell & regenerative medicine good news including Fate Therapeutics

January 13, 2019 / Professor Paul Knoepfler, Ph.D. / 6 Comments

In the past month or two there has been a steady stream of good news in the stem cell and regenerative medicine world. Here are three examples starting with Fate Therapeutics. Fate Therapeutics Fate Therapeutics announced the first US IND for an induced pluripotent stem cell (IPSC)-related product. Its cleared product, FT500, is an off-the-shelf

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Good final grades on my 20 x 2018 stem cell predictions

December 26, 2018 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Each year I make a list of stem cell predictions for the following year and I’ll release my predictions for 2019 soon, but first I’m grading how my 20 predictions for 2018 turned out. It seems I did better than usual predicting what would happen this year. I only got a couple partial credit or

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Midterm grades on my 20 x 2018 stem cell predictions

June 27, 2018 / Professor Paul Knoepfler, Ph.D. / 3 Comments

Every year in December I go out onto a limb and make stem cell predictions for the coming year as I did in late 2017 for this year. Then usually around the 1/2-way point through the year I check in on how the predictions are faring so far at that point. In this post I give

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Japan conditionally approves new IPS cell-based heart study

May 20, 2018 / Professor Paul Knoepfler, Ph.D. / 5 Comments

Yoshiki-Sawa-IPS-cells-stem-cells-heart-diseease

Where do things stand with IPS cell translational research? The newest development is that regulators in Japan just have given conditional approval to an Osaka University team to an induced pluripotent stem (IPS) cell-based study for ischemic heart disease. For years IPS cell-based products have been on-again off-again in active clinical study for macular degeneration, work

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Perspectives on new stem cells for vision loss paper

April 8, 2018 / Professor Paul Knoepfler, Ph.D. / 11 Comments

F2-Kashani-et-al.-Stem-cells-for-vision-loss

Do stem cells for vision loss offer real hope? I believe so, but it’s a long road and must be done right. A new paper in this area generated some buzz on top of an earlier recent pub (mentioned in this post) just a week or so ago about the potential of stem cells for vision

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Adverse event in IPS cell (ips細胞) trial for vision loss in Japan: initial perspectives

January 16, 2018 / Professor Paul Knoepfler, Ph.D. / 3 Comments

A team of researchers at RIKEN and Kobe City Medical Center reported at a press conference today a serious adverse event in a clinical trial participant receiving an induced pluripotent stem cell (IPS cell)-based therapy for vision loss. According to Japan Times and Yahoo! Japan (in Japanese), the patient in question in the IPS cell

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