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Regenerative reads: brain organoids, Clinicaltrials.gov change

February 28, 2021 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Sometimes change takes a very long time, but with brain organoids or advocating for better information for patients at Clinicaltrials.gov, after waiting you can see some interesting developments. These are two of the regenerative medicine stories of the week, along with some striking research papers. Clinicaltrials.gov Some of us have been advocating for improvements at […]

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How much does platelet rich plasma or PRP injection cost? Is it a good option?

February 3, 2021 / Professor Paul Knoepfler, Ph.D. / 2 Comments

prp cost polling data, platelet rich plasma

How much does platelet rich plasma or PRP injection cost? We might start by first talking about how to define PRP. PRP is an extract from blood enriched for platelet growth factors. There are many ways of making PRP and products are very heterogeneous. Some preps may contain actual platelets or fragments of platelets. These

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Duke Autism Center has Panama clinic to thank for $10s millions?

October 13, 2020 / Professor Paul Knoepfler, Ph.D. / 10 Comments

Drs.-Neil-Riordan-and-Joanne-Kurtzberg-MSCs-for-autism

What do a Panama stem cell clinic and the Duke Autism Center have in common? More than I might have imagined. It’s a remarkable story that needs telling. Duke Autism Center There is a puzzle when it comes to the controversial idea of using cord blood for autism. Why? Because two of the strongest proponents

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Duke Autism Center trial: no benefit of cord blood for autism

May 20, 2020 / Professor Paul Knoepfler, Ph.D. / 12 Comments

A solid new, blinded placebo-controlled Phase II study from the Duke Autism Center clearly shows no benefit of cord blood for autism. Surprisingly, the team has said they are encouraged by the results. As a result, they apparently will continue this kind of work anyway despite their data. In contrast, I see the data as a

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Authors on The Niche

May 15, 2020 / Professor Paul Knoepfler, Ph.D.

The Niche has had many authors over the years, focusing on expertise in the biomedical arena and in particular related to stem cells. I’ve invited many authorities in particular areas to write posts. Over the years I’ve written probably 99+% of the posts here on The Niche, but we’ve also had some great guest authors

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Scientists try not to lose it with their labs shut by the pandemic

May 5, 2020 / Professor Paul Knoepfler, Ph.D. / 2 Comments

How can we scientists find ways to keep doing our research during the COVID19 pandemic even if it has nothing to do with the coronavirus? Also, how should those of us involved in science communication talk about the outbreak? At a more basic level, how can scientists try not to go bonkers during this dark

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The Niche COVID-19 updates & resources

March 10, 2020 / Professor Paul Knoepfler, Ph.D.

stem-cells-for-COVID-19-infographic_small

The novel coronavirus and the disease it causes, COVID-19, have swept the world with few proven treatment options. Vaccines are only recently being rolled out the last 2 or so months, which gives some real hope. While the novel coronavirus-caused illness is generally a mild disease in kids (many of whom don’t even show symptoms),

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Upbeat poll results on the future of CIRM funding

January 21, 2020 / Professor Paul Knoepfler, Ph.D. / 11 Comments

I recently started 2 polls on the future of CIRM. The polls are focused on the effort led by Robert Klein to get more funding from the State of California for the stem cell agency. They asked readers about whether Californians will refund CIRM and whether Californians should refund CIRM. Basically, the polls are asking

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Mystery of wild sci-fi film ad for unproven exosomes: Liveyon?

January 15, 2020 / Professor Paul Knoepfler, Ph.D. / 8 Comments

What’s Liveyon up to these days? A new, somewhat mysterious short film that serves as an advertisement for unproven exosomes has some of us scratching our heads. It seems to point to Liveyon. Can you guys as readers of The Niche help solve the puzzle of who’s behind this wild “cinematic commercial” and what the

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Why did clinic supplier Liveyon halt sales but others kept going despite FDA?

December 16, 2019 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Umbilical “stem cell” supplier Liveyon has suspended sales of its products according to the WaPo after a harsh FDA warning letter. While not fully shutting off the tap to the perinatal stem cell clinic universe, as other suppliers including in Utah seem to be continuing, this Liveyon voluntary hold will equal a major reduction in

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