This edition of The Niche weekly reads has a bit more good news than usual including on stem cell transplants. It’s nice to see positive developments like some recipients of hematopoietic stem cell transplants being able to stay at home afterwards. Also, a reminder. You have until July 31 to enter our stem cell video […]
The FDA grace period for stem cell clinics and others using regenerative medicine products like stem cells is over. It appears the agency is serious about enforcement moving forward. They have released several statements about the end of what they call the “enforcement discretion” period, which just means in English a grace period for marketers
Translating the FDA’s Q&A on end of stem cell grace period Read More »
The paper of the week is from Science on making ovarian follicles and actual eggs from stem cells. It’s just in mice, but this line of work tends to stir people up. We’ll dive into that in a moment. But first some good news. We’re up to 146 subscribers on our stem cell YouTube channel
Weekly reads: stem cells to gametes, no PRP benefit, WHO CRISPR, pubs Read More »
Could stem cell Alzheimer’s Disease (AD) research provide a potential path to future treatment or preventative measures? The goal of today’s post is to provide a review of the state of the field in this area including possible approaches and challenges. You can watch a video covering the topic by Dr. Paul Knoepfler below on
Stem cell Alzheimer’s disease research Read More »
The paper of the week is An isoform of Dicer protects mammalian stem cells against multiple RNA viruses published in Science. The take-home from the abstract is that the data, “demonstrate that mammalian stem cells can protect themselves from some RNA viruses by expressing an alternatively spliced isoform of the enzyme Dicer called aviD, which potentiates
Let’s start off today’s recommended reads with the topic of life extension. No controversy there, right? This comes to mind because of a new preprint from BioViva, Liz Parrish, and George Church. I’m hoping to cover this on our Stem Cell Channel on YouTube. Gene therapy and life extension research The preprint is entitled, “New
Weekly reads: life extension & BioViva, clinics & anti-vax, axolotls, systemic CRISPR Read More »
A few years ago a promotional website called Bioinformant popped up in the stem cell arena. It’s very different in some ways than most other stem cell-related websites that I’ve seen. It’s a marketing and promotion site. What’s the backstory? I believe there’s reason for concern here specifically related to Bioinformant promoting unproven stem cell
Review of Bioinformant, unproven stem cell clinic promotion, NIH & Pfizer as clients? Read More »
The International Society for Cell & Gene Therapy or ISCT held a really interesting webinar yesterday on the FDA and unproven stem cell clinics. It was focused on the expiration of the FDA’s discretionary period on unproven stem cell clinics. What will the FDA do now? The webinar included some ideas and also quite a
New data on stem cell clinics, INDs, & more including from FDA itself Read More »
When someone uses the term “adult stem cells” you might think that simply means stem cells from adults. However, it’s not that simple. The goal of today’s post is to help you get all the key facts about adult stem cells. This includes the different types of adult stem cells and their clinical potential. What
What are adult stem cells & their clinical applications? Read More »
After the COVID-19 pandemic started clinical trials quickly sprouted up to test various kinds of cell therapy for COVID-19 including stem cells. The most common rationale for this approach is to suppress damaging overactive immune responses. Trials of cell therapy for COVID-19 including stem cells I’ve written quite a lot about these cellular medicine and
Our new paper assessing trials of cell therapy for COVID-19 Read More »