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Weekly reads: brain aging, perinatal stem cell clinics, $1M lab meat fine bill

February 18, 2024 / Professor Paul Knoepfler, Ph.D. / 1 Comment

What happens during brain aging and how can we tell if dementia is coming? Are there particular early hallmarks? There are an increasing number of medical tests for predicting or detecting dementia. Alzheimer’s disease can often be detected early. But what do patients or their doctors do with such information? Until recently there weren’t any […]

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Weekly reads: cool olfactory tuft cells, T-cell therapy, NK cells

February 11, 2024 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

Olfactory epithelium, Olfactory histology

There’s a fascinating type of olfactory cell. These so-called tuft cells have unusual characteristics, especially for nose cells. I had never heard of them before until reading a new article. The inside of the nose may not seem like a very attractive place but there are cool “nose stem cells” in there. More broadly, there

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Long-term hope on stem cells for deafness

February 1, 2024 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

A reader of The Niche recently asked me, “What about stem cells for deafness?” It’s a great question and, as they pointed out, stem cells for vision loss gets much more attention. I’ve covered the translational progress of stem cells to treat many diseases but there has been less progress for deafness in the regenerative

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Perspectives 10 years after STAP cells: the culture of science, misconduct, & hopes for progress

January 29, 2024 / Professor Paul Knoepfler, Ph.D. / 6 Comments

Exactly ten years ago today, on January 29, 2014, I wrote about two new Nature papers on so-called STAP cells. The papers claimed that stress alone could convert regular non-stem cells into some of the most powerful stem cells. More specifically, the authors claimed to make pluripotent stem cells similar to iPS cells this way.

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Weekly stem cell reads: cancer paper mess at DFCI, H3.3, knees, surfer keeps on posting

January 28, 2024 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

Sholto David, stem cell, cancer retractions

It’s another one of those ‘double-grant’ weekends of grant writing (on brain cancer) and reviewing, but I’m still trying to find a bit of time for some other reading. There was some important news this week including a big mess of problematic papers at Dana Farber Cancer Institute (DFCI). Recommended reads Here’s the new WaPo

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Textbook case of bad media on ‘stem cell treatment’ clinic: Kirk Cousins Caribbean trip

January 24, 2024 / Professor Paul Knoepfler, Ph.D. / 9 Comments

It’s frustrating to see so much bad media coverage of celebrity trips to clinics to get supposed stem cell treatment of various kinds. Part of the concern here stems from ordinary people taking risks by following the example of the famous people. Good journalism should ask tough questions, talk to experts, and not yield an

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Weekly reads: Vertex & CRISPR Therapeutics, Arnold Caplan death, MS genetics

January 14, 2024 / Professor Paul Knoepfler, Ph.D. / 5 Comments

The biotechs Vertex and CRISPR Therapeutics have an interesting relationship as biotechs. They are partners are multiple levels but also are very different as companies including in size. There’s been a key development in one of their partnerships. Before we jump into that, please check out the video version of my 20 stem cell and

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Put on a happy face? Perspectives on Mayo Clinic stem cells for heart disease Ph3 pub

January 11, 2024 / Professor Paul Knoepfler, Ph.D. / 6 Comments

One of the first regenerative medicine talks I ever saw was on stem cells for heart disease. I was still a trainee at the time. The professor, whom I won’t name, presented data from an early phase trial reporting that direct injections of some kind of cells right into the heart improved outcomes. Stem cells

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20 stem cell & regenerative medicine predictions for 2024

January 3, 2024 / Professor Paul Knoepfler, Ph.D. / 4 Comments

Each year I make predictions for the stem cell and regenerative medicine field for the following year. Today’s prediction post is focused on what to expect in 2024. You can also see my stem cell predictions for 2023 and my grades on how I did. I also have made a video version of these predictions so please

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New Year’s reads: having a blastema, gene therapy cost, pathogen lab escape data

December 31, 2023 / Professor Paul Knoepfler, Ph.D. / 4 Comments

Years ago I wrote about how I wished humans could form a blastema, which is a special area of regeneration near an injury that drives tissue replacement. For example, when a lizard loses its tail to a pursuing bobcat, if it can regrow a new one that process will depend on a blastema. The same goes

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