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Recommend reads: CRISPR baby guy free, DNMT3, sperm, Editas, hearing loss, reprogramming

April 17, 2022 April 17, 2022 / By Professor Paul Knoepfler, Ph.D. / 3 Comments

We often don’t think of them that way but reproductive cells like sperm and egg are also relatives of stem cells, and it turns out that there are stem cells that make the reproductive cells too like sperm stem cells. Sperm and germ cell stem cells DNMT3A-dependent DNA methylation is required for spermatogonial stem cells …

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Altos Labs: mission, leadership, jobs, & CIRM

April 12, 2022 April 12, 2022 / By Professor Paul Knoepfler, Ph.D. / 3 Comments

At the beginning of the year I wrote about a new kind of biotech called Altos Labs. It’s very different in some ways from other institutions. I find it an intriguing research entity. Where do things stand now with Altos Labs a few months later? More information, new ideas, and questions have popped up in the …

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FDA news: warning letter pattern, cancer moonshot, CAR-T & gene-editing guidance

March 17, 2022 March 17, 2022 / By Professor Paul Knoepfler, Ph.D. / Leave a Comment

The FDA has been busy with the COVID pandemic but it has many other things on its plate as well including cell therapies. Today I’m sharing some recent agency news and brief perspectives on it. FDA focus on clinic-related umbilical cord cell drug makers The agency warned an Idaho company that produces and sells umbilical …

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Feds want $3M, prison for Liveyon founder in old fraud case

March 2, 2022 March 2, 2022 / By Professor Paul Knoepfler, Ph.D. / Leave a Comment

Before starting the umbilical cord cell supplier and marketing firm Liveyon, John Kosolcharoen was involved in some alleged health care fraud. The feds brought a case against him related to prescription drugs. Older case coming to a head As Liveyon was having its misadventures in the stem cell clinic sphere, the status of that past …

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Weekly reads: R01 grant trends, DPPA4, adult human neurogenesis debate

November 21, 2021 November 21, 2021 / By Professor Paul Knoepfler, Ph.D. / Leave a Comment

Great ideas and talented scientists are not enough as biomedical research needs funding and here in the U.S. that means having R01 grant success. The trends since 1995 are slowly heading the wrong way. The average age of getting your first R01 grant keeps getting older. There is also still a bit of a possible …

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Liveyon product hurt many more patients says new CDC study

October 26, 2021 October 25, 2021 / By Professor Paul Knoepfler, Ph.D. / 1 Comment

Liveyon is a cord blood product marketer that distributed a batch of cells a couple of years back that led to many patients being hospitalized with infections. Some had sepsis and ended up in the ICU. It was thought at the time that about a dozen patients who had been injected with the Liveyon product …

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Fact-checking Regenexx: reviews, data & cost

October 5, 2021 December 28, 2023 / By Professor Paul Knoepfler, Ph.D. / 23 Comments

Map of Regenexx stem cell locations. Screenshot of map from company website.

Stem cell clinic firms often come and go rather quickly, but a few like Regenexx have persisted. It’s even become a brand name. I’ve been writing here on The Niche for more than twelve years about stem cell clinics. Regenexx has been around that whole time. Along with its founder Dr. Chris Centeno. Patients have …

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Human cloning is more likely now but would you take the big risks?

September 8, 2021 September 8, 2021 / By Professor Paul Knoepfler, Ph.D. / 3 Comments

I’ve been following the research related to human cloning now for more than a decade. Is human cloning more possible at this point? How do we even define such cloning? Did you know there are two types? The goal of this post is to educate you and in the process answer such questions. What’s in …

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Risks rise as ISSCR drops strict 14-day rule on human embryo growth in the lab

May 27, 2021 May 27, 2021 / By Professor Paul Knoepfler, Ph.D. / 3 Comments

Something called the 14-day rule on growing human embryos in the lab helped keep a tough question in check for a long time: when is it ethically wrong or just practically unwise to continue growing a human embryo for research? There is no good answer based on science or anything else. ISSCR moves beyond strict …

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