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Challenge of Yamanaka Patent by BioGatekeeper Fails

February 16, 2015 / Professor Paul Knoepfler, Ph.D. / 15 Comments

The still mysterious BioGatekeeper had challenged Yamanaka’s IPS cell patent claiming that it was obvious. The potential implications were huge given the commercial interest in translating IPS cell technology. For background see here, here, and here. There’s pretty much zero information on BioGatekeeper otherwise. Despite the potential seriousness of this patent challenge, just a few days […]

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The Odd Couple of Cloning Research: Mitalipov & Woo Suk Hwang Unite

February 11, 2015 / Professor Paul Knoepfler, Ph.D. / 13 Comments

Remember that old TV show the Odd Couple with very proper Felix Unger and his polar opposite Oscar Madison who has all kinds of baggage? They’ve cloned it into a remake to be on TV soon here in the US in 2015. It seems only fitting then that actual human cloning research has a new

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Keith Olbermann, the Dr. Oz of Sports?

February 5, 2015 / Professor Paul Knoepfler, Ph.D. / 26 Comments

There was a time I used to watch Countdown with Keith Olbermann on a regular basis and for a few years, I really enjoyed it. After a while I kind of lost interest. Today Olbermann does a sports show on ESPN and it’s just not the same. He also seems like he’s not the same

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Silva Comments on MBD3/NuRD Debate with Jacob Hanna

January 25, 2015 / Professor Paul Knoepfler, Ph.D. / 10 Comments

What’s the deal with the tension between José Silva and Jacob Hanna over pluripotency? Researchers probing how to reprogram cells into powerful stem cells (induced pluripotent stem cells or IPSCs) and what the molecular mechanisms are behind this process have become entangled in a conflict. Of course over the years scientists including stem cell scientists have

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This is your brain on diapers: new mindbogglingly cool imaging trick

January 25, 2015 / Professor Paul Knoepfler, Ph.D. / 1 Comment

In what NIH describes as “outside-the-box” thinking, an MIT team led by Edward Boyden has found a way to use a diaper ingredient to transform microscopy including brain imaging. This is cool stuff. Boyden’s group found that the super-absorbent diaper compound sodium polyacrylate, can be used in a very novel way for microscopy. For any who have

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The Lake Wobegon Effect in Science: Where Every Paper is Above Average

January 18, 2015 / Professor Paul Knoepfler, Ph.D. / 5 Comments

Garrison Keillor’s NPR show A Prairie Home Companion would sometimes report from a small fictional town call Lake Wobegon. Frankly, I found that show really boring, but I always chuckled when I heard this line: “Well, that’s the news from Lake Wobegon, where all the women are strong, all the men are good looking, and

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Post-Publication Paper Reviews & Commentaries

January 2, 2015 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

2015 Review of Vogelstein “Bad Luck” Cancer & Stem Cell Paper in Science January 02, 2015 2014 What Does New Paper Mean for Future of Nuclear Transfer ES Cells? November 9, 2014 Encouraging New Paper on ACT Stem Cell-Based Trial for Macular Degeneration October 14, 2014 Top 10 Takeaways From Harvard Stem Cell Diabetes

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Review of Bert Vogelstein “Bad Luck” Cancer Science pub

January 2, 2015 / Professor Paul Knoepfler, Ph.D. / 34 Comments

A new paper in Science by Bert Vogelstein suggests that a good part of cancer is attributable to bad luck. There are so many big questions about cancer. They resonate with me very strongly as a cancer researcher and a cancer survivor myself (more on my cancer story here). What really causes cancer? Why does

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Radical Vision for CIRM Future: Interview with New Prez Mills

December 5, 2014 / Professor Paul Knoepfler, Ph.D.

Change is in the air for the California stem cell agency, CIRM. It has a new President, Randy Mills, and CIRM is soon going to be like a new agency too. I recently did an interview with Mills that illuminates some of the big changes that are imminent. I also asked him what his favorite

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