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Weekly reads: Vertex, stem cells for MS, Athersys, 900-day paper review at Nature

March 3, 2024 / Professor Paul Knoepfler, Ph.D. / 1 Comment

“While still early, these results support the continued progression of our VX-880 clinical studies, as well as future studies using our encapsulated islet cells, which hold the potential to be used without the need for immunosuppression,” said Bastiano Sanna, Ph.D., executive vice president and chief of cell and genetic therapies at Vertex.

Vertex Pharmaceuticals has a lot going for it right now on the cell therapy front. For instance, they have the strongest type 1 diabetes cell therapy pipeline after some recent acquisitions. Still it’s not a simple matter to succeed in the cell therapy space even with one therapy for one targeted disease. Trials are tough […]

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Something Elon Musk & I agree on: pushing back on anti-aging bluster

February 28, 2024 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

Would you guess that Elon Musk might be into using biotechnology in a high-profile way to try to live far longer than usual, say to age 150? That would have been my assumption. There are countless things about Elon Musk that I really don’t like. I also don’t see many issues on which we are

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The zoo that is stem cells on Reddit

February 23, 2024 / Professor Paul Knoepfler, Ph.D. / 9 Comments

Can you learn important things about stem cells on Reddit? Yes, you can, but it’s a wild experience at times. Researchers may often think about stem cells through the lens of traditional routes of communication like academic journals, but laypeople turn elsewhere to learn about regenerative medicine. This includes digging into stem cells on Reddit.

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Weekly reads: brain aging, perinatal stem cell clinics, $1M lab meat fine bill

February 18, 2024 / Professor Paul Knoepfler, Ph.D. / 1 Comment

What happens during brain aging and how can we tell if dementia is coming? Are there particular early hallmarks? There are an increasing number of medical tests for predicting or detecting dementia. Alzheimer’s disease can often be detected early. But what do patients or their doctors do with such information? Until recently there weren’t any

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Weekly reads: cool olfactory tuft cells, T-cell therapy, NK cells

February 11, 2024 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

Olfactory epithelium, Olfactory histology

There’s a fascinating type of olfactory cell. These so-called tuft cells have unusual characteristics, especially for nose cells. I had never heard of them before until reading a new article. The inside of the nose may not seem like a very attractive place but there are cool “nose stem cells” in there. More broadly, there

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9th Circuit hearing on FDA appeal of Cell Surgical Network case: maybe encouraging?

February 7, 2024 / Professor Paul Knoepfler, Ph.D. / 5 Comments

I was able to watch some of the 9th Circuit Court hearing today on the FDA appeal of its loss in the Cell Surgical Network lawsuit. This post is my brief impressions as a scientist. What went down? Do the three judges seem to be leaning one way or another? The ruling in this case

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Long-term hope on stem cells for deafness

February 1, 2024 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

A reader of The Niche recently asked me, “What about stem cells for deafness?” It’s a great question and, as they pointed out, stem cells for vision loss gets much more attention. I’ve covered the translational progress of stem cells to treat many diseases but there has been less progress for deafness in the regenerative

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Perspectives 10 years after STAP cells: the culture of science, misconduct, & hopes for progress

January 29, 2024 / Professor Paul Knoepfler, Ph.D. / 6 Comments

Exactly ten years ago today, on January 29, 2014, I wrote about two new Nature papers on so-called STAP cells. The papers claimed that stress alone could convert regular non-stem cells into some of the most powerful stem cells. More specifically, the authors claimed to make pluripotent stem cells similar to iPS cells this way.

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Weekly stem cell reads: cancer paper mess at DFCI, H3.3, knees, surfer keeps on posting

January 28, 2024 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

Sholto David, stem cell, cancer retractions

It’s another one of those ‘double-grant’ weekends of grant writing (on brain cancer) and reviewing, but I’m still trying to find a bit of time for some other reading. There was some important news this week including a big mess of problematic papers at Dana Farber Cancer Institute (DFCI). Recommended reads Here’s the new WaPo

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Weekly reads: MiMedX & Kimera Labs FDA warnings, NYT on Bryan Johnson, MUSE cell trial

January 21, 2024 / Professor Paul Knoepfler, Ph.D. / 10 Comments

Placental biologics firm MiMedx and exosome company Kimera Labs both recently received FDA warning letters. The letter to MiMedx was related to its placental biologics products and procedures. The new warning to Kimera Labs was about its exosome products and an amniotic product. Let’s compare these letters starting with the one to MiMedX. MiMedx warning letter

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