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Weekly reads: BioViva & life-extension clinic, RMATs, universal cells

May 14, 2023 / Professor Paul Knoepfler, Ph.D. / 2 Comments

BioViva CEO Liz Parrish in YouTube video.

I’ve written before about Liz Parrish and her life-extension firm BioViva. Now they appear to have connections with another entity called Integrated Health Systems or IHS, according to a new Wired article. Some of what is going on with IHS and maybe BioViva in Mexico seems extremely risky to me. BioViva, Parrish, and Integrated Health Systems The […]

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Weekly reads: stem cells for ALS, cell wrinkles, editors quit

May 7, 2023 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

I’ve been writing The Niche now for more than 13 years and the idea of stem cells for ALS has been around that whole time. Unfortunately, it has been slow going on this front, but there are still reasons for hope. Probably now much more than ever before. I’ll start with news on one path

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Can stem cell therapy for back pain work?

May 3, 2023 / Professor Paul Knoepfler, Ph.D. / 3 Comments

I often get asked about where things stand with stem cell therapy for back pain, which is the focus of today’s post. Back pain is a complex condition with many potential causes. New treatments are needed as existing approaches often don’t work that well. What about stem cells? Stem cell therapy or other cell therapy

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Weekly reads: reprogramming hearing loss, heart disease, eye drops, sickle cell

April 30, 2023 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

It’s mostly been a week of good and encouraging news in the regenerative medicine space including with gene therapies maybe with the exception of some eye drops warnings (more below). There’s realistic hope for an approved sickle cell disease soon. I also see some long-term positive news on hearing loss research. Hematopoietic stem cell transplant

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Weekly reads: FDA nod on new cell therapy, gray hair, pong-playing cells

April 23, 2023 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

It’s a big challenge to get a cell therapy approved by the FDA and if you look at my list of FDA-approved stem cell therapies, it’s not as long as we might hope. FDA OK on cell therapy from Gamida Cell For this reason, it was excellent news to see that the FDA approved a

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WHYY oh WHYY: NPR puff piece on risky stem cell microneedling

March 14, 2023 / Professor Paul Knoepfler, Ph.D. / 2 Comments

I usually associate NPR with solid journalism so I was scratching my head about a recent puff piece by WHYY on stem cell microneedling. Is this journalism or product promotion? The NPR piece by Maiken Scott doesn’t ask important questions. Scott received stem cell microneedling herself using a product from a company called AnteAGE. How

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Heart stem cells trial mostly disappoints but is oversold

March 2, 2023 / Professor Paul Knoepfler, Ph.D. / 6 Comments

Are there endogenous adult heart stem cells that are useful in cardiac disease or can stem cell infusions help ailing hearts? As to the first question, the adult heart does not appear to have meaningful numbers of true stem cells. Further, testing the idea of infusions of stem cells for heart disease has so far been giving

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Does NurOwn from BrainStorm Cell Therapeutics still provide hope for ALS?

February 22, 2023 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

Chaim Lebovits, CEO of BrainStorm Cell Therapeutics.

What is the cell therapy for ALS called NurOwn? How strong is its potential as a treatment for ALS? I’ve been following the biotech BrainStorm Cell Therapeutics for many years. Patients keep asking me about NurOwn ALS prospects. They’re looking for hope. Today’s post is a close look at NurOwn and at BrainStorm as a

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LifeWave X39 stem cell patch story has holes

February 14, 2023 / Professor Paul Knoepfler, Ph.D. / 253 Comments

I often learn about new supposedly stem cell-related products like the LifeWave X39 Patch from readers. Sometimes such products are used by tens of thousands of people, in my view potentially raising risks to the public. If nothing else, people might be spending their money on something that isn’t worth it. As a stem cell biologist,

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Weekly reads: stem cell niche & AI stumble on health

February 12, 2023 / Professor Paul Knoepfler, Ph.D. / 2 Comments

What is a stem cell niche? It’s the home of stem cells. The stem cell niche is a fascinating environment. It has many constituents that impact stem cell behavior and even eventual stem cell transplant functions. In today’s weekly reads, we’ll start with the niche as there have been several interesting papers on this topic. The

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