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Autologous or Allogeneic: a stem cell question (guest post from Jeanne Loring)

January 19, 2019 / Professor Paul Knoepfler, Ph.D. / 20 Comments

stem-cells-and-development-parkinsons-disease

By Jeanne Loring What can you do with cells that live forever and can make every cell type in the body? The answer is: remarkable things, as new reports of clinical trials using cell types derived from pluripotent stem cells indicate. Pluripotent stem cells are either derived from embryos donated from IVF procedures (human embryonic […]

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Stem cells for autism: time to hit pause in 2018?

October 22, 2018 / Professor Paul Knoepfler, Ph.D. / 9 Comments

Stem cells for autism? After watching this area for many years, I’m not sure there’s any “there there”. There are logical reasons to think that certain stem cells might help many specific diseases, but in my view autism isn’t likely to be one of them. I hope I’m wrong, but today at least in 2018,

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Papers on artificial embryos and muscle stem cells

October 7, 2018 / Professor Paul Knoepfler, Ph.D. / 1 Comment

If you are sick of the general news lately, I recommend turning to the wonder of cool science like the thought-provoking data in the duo of new stem cell pubs discussed below including on artificial embryos. Synthetic embryos A team led by Alfonso Martinez-Arias reports new findings in their Nature letter in the growing area

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60 Minutes Australia Pushes Unproven Stem Cells for Cerebral Palsy

August 22, 2018 / Professor Paul Knoepfler, Ph.D. / 5 Comments

A stem cells for cerebral palsy 60 minutes ad.

The 60 Minutes show here in the U.S. has done sobering segments over the years on risky, unproven stem cell clinics, but now there is a new episode of 60 Minutes Australia that is the polar opposite: it mostly made a mess of things with its fluffy coverage of the story of a wonderful little

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Tarek El Moussa stem cell shot, a flip or a flop? Risks of celeb buzz

May 24, 2018 / Professor Paul Knoepfler, Ph.D. / 1 Comment

The world is constantly bombarded these days with often-hyped stories of the latest celebrities who got unproven stem cells, including most recently Jack Nicklaus and now Tarek El Moussa of Flip or Flop TV real estate fame. Both these celebs got stem cells for orthopedic kind of health situations, but while in theory stem cells

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Divots fly from CNN puff piece on Jack Nicklaus & unproven stem cells

May 2, 2018 / Professor Paul Knoepfler, Ph.D. / 4 Comments

CNN-puff-piece-stem-cells-screenshot-from-video

This past week’s coverage of unproven stem cells exhibited a wide range both in tone and in topics including golfer Jack Nicklaus. There were the three critical articles on clinics that I blogged about earlier and then there was a CNN puff piece by Dr. Sanjay Gupta and Roni Selig mostly focused on Nicklaus. Note that

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Predatory clinics push stem cell secret society, deep state conspiracy theory

January 29, 2018 / Professor Paul Knoepfler, Ph.D. / 5 Comments

conspiracy-theory-stem-cells-deep-state-e1516141862445

Did you hear the one about the deep state FDA, big pharma stem cell conspiracy theory? This is the phony idea that the FDA, big pharma, and, heck, sometimes even certain academics (who could that be?) are plotting together as some kind of biomedical secret society or “deep state” to block promising stem cell therapies

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Seattle clinic uses FDA commish in marketing non-FDA approved stem cells

December 18, 2017 / Professor Paul Knoepfler, Ph.D. / 4 Comments

Generation-stem-cell-clinic-ad-Seattle-Times

How far will stem cell clinics go to market their non-FDA approved “treatments” that they often claim will have miraculous results? I’ve never seen anything quite as striking as what some clinics in the Seattle area are now doing. In the past, we’ve seen clinics take researchers’ pictures, quotes, or videos to use for their

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Customers rate Nervana stem cell clinic harshly on Yelp

September 7, 2017 / Professor Paul Knoepfler, Ph.D. / 11 Comments

Sacramento’s Nervana stem cell clinic has been selling non-FDA approved stem cell therapies to patients for a variety of conditions including arthritis, pain, and neuropathy for a while now since last year, but in my opinion there isn’t good evidence to back up using amniotic or fat stem cells for such conditions. Further, my understanding

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Stem cell transplants: hIPSC and hESC behave similarly in brain & often fuse with host cells

August 24, 2017 / Professor Paul Knoepfler, Ph.D. / 8 Comments

What happens following pluripotent stem cell transplants into the brain? Are human IPS and ES cells going to function similarly in this context? We recently published a new translational paper on the behavior of human pluripotent stem cells when transplanted into the adult mouse brain in collaboration with my great UC Davis colleague, Dr. Veronica Martinez-Cerdeno.

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