September 19, 2020

The Niche

Knoepfler lab stem cell blog

Month: April 2014

4 min read

It was intriguing last week to read about another advance in somatic cell nuclear transfer (SCNT)-based therapeutic cloning of human embryonic stem cells (hESC). The first such work was published last year by Mitalipov’s group from OHSU. This second paper to produce so-called nuclear transfer hESC (NT-hESC) made the important advance to show that it could be done using adult and even old human somatic cells. This is a reproducible technology, which is very important. However, key challenges and concerns remain for human therapeutic cloning …Read More

1 min read

Sometimes when we Google things we can find out surprising things about specific topics including the whole STAP cell train wreck. When I recently searched for STAP, here was my reaction: What the heck? A recent Google search for STAP cells yielded these two adjacent, completely contradictory results sourced from two Obokata mentors (see image above) by the same newspaper less than 1 day apart. That certainly clears things up on the STAP cell front, huh? Are they a hypothesis or “undoubtedly exist”? Neither, …Read More

3 min read

An international team of stem cell scientists has replicated human therapeutic cloning to make embryonic stem cells via somatic cell nuclear transfer (SCNT). The team was led by Drs. Dong Ryul Lee of CHA Stem Cell Institute in Korea and Robert Lanza of Advanced Cell Technology (ACT) and reported the advance in the Chung, et al. paper today in the journal Cell Stem Cell entitled “Human Somatic Cell Nuclear Transfer Using Adult Cells”. The cells expressed pluripotency markers (see Figure 1A at left) and …Read More

5 min read

The ultimate fate of the two Nature STAP cell papers remains in troubled limbo. One of the senior STAP cell authors, Dr. Sasai, held a news conference yesterday in Japan that included a call for the papers to be retracted. He was variously quoted as believing in STAP cells or alternatively as just thinking it was an unproven hypothesis. Whether STAP cells or STAP stem cells are real or not, overall the STAP cell situation has been disastrous. Can biomedical science learn anything from this …Read More