August 6, 2020

The Niche

Knoepfler lab stem cell blog

Diabetes Stem Cell Milestone: ViaCyte Transplants 1st Patient

viacyte encaptraChalk up another exciting development for the stem cell and regenerative medicine field in 2014. It’s been a huge year.

For the first time ever, an ES cell-based device has been transplanted into a Diabetic patient.

ViaCyte working together with Dr. Robert Henry at UCSD did the pioneering transplant, the first in a series as part of an FDA-approved clinical trial being conducted as UCSD Health System.

The trial is a combined Phase I/II testing the safety of ViaCyte’s VC-01 product.

The PR says, “In an open-label, dose-escalating format, ViaCyte expects to enroll approximately 40 patients in the study at multiple clinical sites.” It is entitled “A Safety, Tolerability, and Efficacy Study of VC-01™ Combination Product in Subjects With Type I Diabetes Mellitus.”

VC-01 employs human pancreatic progenitor cells derived from human ES cells. The rationale here is that in preclinical studies the cells were shown to have a significantly positive influence on blood sugar in Diabetic mice.ViaCyte New Logo

This is an exciting, positive development for the field and for patients. I can’t wait to see how the trial goes and am cautiously hopeful.

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