August 15, 2020

The Niche

Knoepfler lab stem cell blog

Big push for 3-parent technology in UK: some thoughts from the other side

3-parent babyA new piece came out yesterday on the Wellcome Trust Blog, strongly promoting approval of so-called “3-Parent IVF” or Mitochondrial Transfer technology by the UK Parliament.

As I written in the past (here and here), my view is that this would be a mistake at this time.

There is room for respectful disagreement on this issue between scientists, although I realize I’m up against some very prominent scientists including Drs. Peter Braude and Robin Lovell-Badge, whose past response to my open letter to the UK Parliament was one that I published on my blog here.

I believe in presenting both sides and I respect Drs. Braude and Lovell-Badge greatly.

The new Wellcome Trust blog piece includes a letter signed by a host of additional top scientists and other prominent figures encouraging parliamentary approval of 3-parent technology (see the letter at the bottom of this post).

This letter is signed by 5 Nobel Laureates and even some UK royalty.mito

Do I really want to be on the other side from those folks too?

Not really, but I need to call it like I see it and this is an important issue.

I seem to be one of the few scientists including stem cell scientists who will publicly say that I believe we need to learn a lot more about this technology before it is used on humans.

There is no doubt that mitochondrial diseases are truly terrible and need to be addressed, but if the potential outcomes from the technology are still vague, there are safety concerns, and it raises profound ethical issues such as changing the human genome heritably as is the case here, then my view is that a careful approach is both practical and logical. We cannot at this time have a reasonable expectation that this technology would be safe and effective. That may change in coming years with new knowledge. I hope so.

As strange as it may sound, although mitochondria have been studied for around 150 years, they remain in many ways still a new frontier for science with many mysteries. We are only now, for example, starting to understand how the mitochondrial genome works. There was just recently a very unexpected discovery that the mitochondrial genome produces thousands of potentially powerful non-coding RNAs with largely unknown functions. Nobody has any clue how these RNAs might behave in the context of mitochondrial transfer.

What else we will learn about mitochondria in coming years that is unexpected? I’d venture to say many mitochondrial surprises are still to come and there may well be things that we wish we knew in advance before we did human mitochondrial transfer. Science only has a very shallow depth of knowledge about mitochondria and new powerful genomics technologies are poised to change that quickly. I favor waiting until we learn more before we transfer mitochondria.

Still, since there are so many big name folks on the other side including many I greatly respect, could I be wrong?

Maybe.

Am I making a mistake publicly taking the other side?

Perhaps.

To be clear, I have no “iron in the fire” as the expression goes on this issue myself. I don’t work on this area of science or a competing area. It makes no practical difference to me whether the UK goes forward with mitochondrial transfer. If anything, my speaking out could be negative to me as I am taking what seems to be an unpopular, public stance.

The UK House of Commons will debate this issue this coming Tuesday, February 3rd.

Here’s the letter pushing for approval of this technology.

3-person technology letter

 

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