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New human genome editing (HHGE) academy report: solid, but key gaps

September 8, 2020 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

The-International-Commission-on-the-Clinical-Use-of-Human-Germline-Genome-Editing-HHGE

Something called, “The International Commission on the Clinical Use of Human Germline Genome Editing” has issued a new report on heritable human genome editing (HHGE). The Commission was convened by the U.S. National Academy of Medicine, the U.S. National Academy of Sciences, and the U.K.’s Royal Society. This post is my initial take on the summary of […]

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Mixed messages on CRISPR babies from National Academies versus their experts: a look at new Science piece

December 13, 2018 / Professor Paul Knoepfler, Ph.D. / 4 Comments

Three national academy leaders have a new opinion piece in Science on what the community needs to do next regarding human germline editing now that we are most likely in the CRISPR babies era. Some of us have been wondering what the Academies and their empowered experts really think about this issue and what they

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Xenobots, Zambonis, and cellular hype

December 7, 2021 / Professor Paul Knoepfler, Ph.D. / 1 Comment

A clever idea to try to use AI to make cellular machines has produced something being called xenobots. However, the research is getting overblown in some ways. What does this have to do with Zambonis? Read on. What are xenobots? A xenobot is supposed to be a cellular robot made from frog stem cells. The robot part

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Where are all the new CRISPR human embryo papers?

August 25, 2016 / Professor Paul Knoepfler, Ph.D. / 4 Comments

Last year I heard from several sources that there somewhere between 3-5 unpublished manuscripts reporting the use of CRISPR gene targeting in human embryos being shopped around at various journals in addition to the one that had been published. Since that time we’ve seen a grand total of one additional paper reporting on CRISPR of human

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UC Davis CRISPR Meeting: Big Picture from Ben Hurlbut

May 26, 2016 / Professor Paul Knoepfler, Ph.D.

The CRISPR meeting has started off wonderfully with a talk by Ben Hurlbut. His talk was entitled, “The Demands of CRISPR’s World: Imagination, Deliberation and Governance”. Since I took notes and listened this post is somewhat freeform. I liked how Ben asked a lot of questions. What is “CRISPR’s world” as Science Magazine called it? How

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UK should freeze mitochondrial replacement as Egli paper ID’s serious problem

May 19, 2016 / Professor Paul Knoepfler, Ph.D. / 1 Comment

An important new Cell Stem Cell paper from Dieter Egli’s lab points to an inherent, serious problem with so-called 3-person IVF or mitochondrial replacement technology that warrants putting an immediate hold on all efforts to use it in humans. I have pasted the graphical abstract from the paper below. For years a few of us scientists and

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NAS proposes prudent US policy on 3-person IVF

February 3, 2016 / Professor Paul Knoepfler, Ph.D. / 3 Comments

A new report from the National Academies of Sciences (NAS), Engineering, and Medicine here in the US recommends a policy significantly more cautious on first read for 3-person IVF than that in place now in the UK. My initial take on this new 164-page report is that it is very well thought out and the

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GOP Congress seeks ban on CRISPR of human embryos

December 16, 2015 / Professor Paul Knoepfler, Ph.D. / 3 Comments

GOP members of Congress want a ban on CRISPR of human embryos. They are moving to block genetic modification of human embryos using the new CRISPR gene editing technology. The new proposed spending bill part way through the approval process with the nugget of good news of a possible NIH spending boost after many years

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Just freakin do it: patients voice impatience on CRISPR for genetic diseases

December 15, 2015 / Professor Paul Knoepfler, Ph.D. / 11 Comments

Both before and particularly now after the big human gene editing summit in Washington, D.C. at the National Academy of Sciences, I’ve talked with patients about their views on this new technology including at last week’s World Stem Cell Summit. One of the most striking moments of the DC summit was when the mother of

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What if I could make designer babies for you? My TED talk

December 8, 2015 / Professor Paul Knoepfler, Ph.D. / 1 Comment

What’s it like to give a TED talk and could there be designer babies in your future as a parent? On Halloween I gave a TEDxVienna talk (click above) on giving consideration to the possibility that we may be headed toward a new reality in the next 15 years in which there are designer babies.

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