Search Results for: cancer

Weekly reads: abundant Abcam prices, speedy aging & cancer, stemmy CAR-T, more on STAP

April 13, 2024 / By / 3 Comments
Abcam prices

When a vendor of important reagents like antibody supplier Abcam charges big money, those high Abcam prices could negatively impact research in the long run. Some of the prices are so high that buying just a few antibodies could take up a small but meaningful slice of an entire R01 grant. Sky-high Abcam prices I’ve …

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Weekly reads: AL embryos ruling, blasting cancer, marrow organoids, beef inside rice plants

February 24, 2024 / By / 23 Comments
Multipotent & totipotent vs pluripotent stem cells, very early human embryos totipotent stem cells

Are small clusters of cells that make up 5-day-old human embryos equivalent to children? Biologically and in terms of just common sense, the answer is “no.” These tiny spheres have around 100 cells and no organs. Actual people have many trillions of cells, brains, and other organs. Alabama law on embryos may block IVF About …

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Weekly stem cell reads: cancer paper mess at DFCI, H3.3, knees, surfer keeps on posting

January 28, 2024 / By / Leave a Comment
Sholto David, stem cell, cancer retractions

It’s another one of those ‘double-grant’ weekends of grant writing (on brain cancer) and reviewing, but I’m still trying to find a bit of time for some other reading. There was some important news this week including a big mess of problematic papers at Dana Farber Cancer Institute (DFCI). Recommended reads Here’s the new WaPo …

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Some CAR-T may very rarely cause new cancers

November 30, 2023 / By / 1 Comment
CAR-T, CAR-T cancer

The FDA issued a statement this week that there have been reports of new cases of blood cancer after patients received CAR-T therapies. The FDA specifically mentions T cell malignancies. New cancers in rare cases? In the announcement, FDA Investigating Serious Risk of T-cell Malignancy Following BCMA-Directed or CD19-Directed Autologous Chimeric Antigen Receptor (CAR) T cell …

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Weekly reads: clonal expansion, Golden Retriever cancer, FTC hits genetics firm on testi-phony-als

November 25, 2023 / By / 1 Comment
clonal selection

Let’s start this week’s digest with a discussion of clonal expansion and mutations during cell and gene therapy development. Here’s the article that brought this to mind. Sickle cell gene therapy process may cause cancer-linked mutations in blood stem cells, Fierce Biotech. Clonal expansion This is a story about a non-CRISPR gene therapy using a …

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Weekly reads: stem cells for epilepsy from Neurona Therapeutics, diabetes, contagious cancer

October 7, 2023 / By / 2 Comments
Neurona Therapeutics, stem cells for epilepsy

People often ask me what are the most promising stem cell therapies in development and new data suggest we should add stem cells for epilepsy to the list based on work by Neurona Therapeutics. I’ll start off the weekly recommended reads with this new mouse paper on cell therapy for epilepsy. Neurona Therapeutics: stem cells …

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Weekly reads: stem cell therapy for eyes research, DMD, cheating death, cancer sensors

September 14, 2023 / By / 1 Comment
stem cell therapy

Many avenues are being pursued to get stem cell therapy to the clinic for eye conditions. These different approaches employ a variety of stem cell types. In some cases, such as with iPS cells, the stem cells themselves are not transplanted. Instead, the iPS cells are used to make differentiated eye cells, such as RPE …

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Weekly reads: $1B Saudi anti-aging push, OCT4 necklace, cancer trial wows, coffee brain

June 11, 2022 / By / 1 Comment
Stem-Cells-Aging, anti-aging

I recently wrote about stem cell-related ideas for anti-aging and even cheating death, but there are of course other approaches including drugs like metformin. A new article outlines a massive research funding plan to tackle aging. Let’s start with that. Recommend reads including anti-aging Saudi Arabia plans to spend $1 billion a year discovering treatments to …

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Weekly reads: fibroblasts, cancer stem cells, Parkinson’s

April 23, 2022 / By / Leave a Comment
fibroblasts stained

It seems like the field of cell biology has mixed feelings about fibroblasts so I’m going to start off there with the recommended reads. But first, check out our stem cell YouTube channel as we are steadily heading toward 500 subscribers and 30,000 views. Please subscribe. I’ve pasted one of our top videos below, which …

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FDA news: warning letter pattern, cancer moonshot, CAR-T & gene-editing guidance

March 17, 2022 / By / Leave a Comment
FDA-draft-guidance

The FDA has been busy with the COVID pandemic but it has many other things on its plate as well including cell therapies. Today I’m sharing some recent agency news and brief perspectives on it. FDA focus on clinic-related umbilical cord cell drug makers The agency warned an Idaho company that produces and sells umbilical …

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