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Weekly reads: cancer stem cells, encouraging findings, Trump & NIH, proteomics

November 10, 2024 / Professor Paul Knoepfler, Ph.D. / 2 Comments

Liver cancer stem cells, cancer stem cells

Cancer stem cells are stem cell-like cells in many tumors that are key contributors to the ability of tumors to persist and recur after treatment. For those reasons, they are also thought to be major targets, including of emerging therapies. Data also suggest that some therapies may create new types of cancer stem cells leading […]

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Weekly reads: Vertex & CRISPR Therapeutics, Arnold Caplan death, MS genetics

January 14, 2024 / Professor Paul Knoepfler, Ph.D. / 5 Comments

The biotechs Vertex and CRISPR Therapeutics have an interesting relationship as biotechs. They are partners are multiple levels but also are very different as companies including in size. There’s been a key development in one of their partnerships. Before we jump into that, please check out the video version of my 20 stem cell and

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New research on CRISPR gene-editing in stem cells, infographic

September 24, 2020 / Mina Kim / Leave a Comment

As a pivotal advance in the gene-editing field and timeline, CRISPR continues to be utilized for research on stem cells and human diseases. Today, I will explain some of the most notable recent findings in the stem cell-CRISPR field. To start things off, I have also created an infographic that briefly explains what CRISPR-Cas9 is,

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CRISPR often damages human embryo chromosomes

July 1, 2020 / Professor Paul Knoepfler, Ph.D. / 3 Comments

Three new studies reported in preprints all show severe DNA damage to human embryos from CRISPR a surprisingly high percentage of the time including in some cases loss of heterozygosity (LOH). Anywhere from about a quarter to half of CRISPR’d embryos exhibited major genome damage. As readers of The Niche know, I never was a

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Heads up on Hui Yang, another potential aspiring CRISPR baby researcher

January 22, 2020 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Making a CRISPR baby is a controversial idea to even propose now for many reasons, yet even after He Jiankui’s train wreck some people have seemed eager to try it including apparently a scientist whose name perhaps many readers here are not so familiar with in this context: Professor Hui Yang. ‘CRISPR baby guys’ Is

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Perspectives on CRISPR baby guy He Jiankui (贺建奎) going to jail

December 31, 2019 / Professor Paul Knoepfler, Ph.D. / 2 Comments

Jiankui-He-who-claims-CRISPR-baby-production

Scientist He Jiankui(贺建奎) has been sentenced to 3 years in prison by Chinese authorities. Two collaborators also will go to jail. A piece in Science by Dennis Normile on the sentencing of He Jiankui ID’d the other two: “His collaborators were identified as Zhang Renli, of a medical institution in Guangdong province, and Qin Jinzhou, from a Shenzhen

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Calling Out Denis Rebrikov CRISPR Babies Plan

June 26, 2019 / Professor Paul Knoepfler, Ph.D. / 1 Comment

A Russian Scientist named Denis Rebrikov told Nature and then other media including NPR last week that he plans to make CRISPR babies. In other words, babies with heritable genetic modifications. I don’t doubt that Rebrikov (pictured in ResearchGate image) might want to do this nor that he might try it, but rather I’m writing

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Who is He Jiankui’s mentor Michael Deem & is he trying to edit himself out of CRISPR baby project?

December 20, 2018 / Professor Paul Knoepfler, Ph.D.

Who is Michael Deem and what was his role in his former student He Jiankui’s purported production of twin CRISPR’d babies? Is Deem now trying to edit himself out of the project? He Jiankui relied on help from many people and Deem was reportedly a part of that team. Members of He’s own research team helped

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Context for my Nature piece on redefining “gene edit” to be more precise

December 19, 2018 / Professor Paul Knoepfler, Ph.D. / 1 Comment

When I say “gene edit” or “genome editing”, what’s the first thing that pops in your mind? It will depend on who you are. For many lay people until a few weeks ago when the world heard about He Jiankui‘s claim of CRISPR’d babies they may not have had anything pop in their heads when

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History tells us to be more skeptical of He Jiankui’s CRISPR baby story

December 9, 2018 / Professor Paul Knoepfler, Ph.D. / 2 Comments

Could He Jiankui have faked part or all of his CRISPR babies story? If so, how? Why? Or to put it another way, almost everyone seems to be assuming the story is real, but should we be more skeptical? Should we flip things around and assume the story isn’t entirely kosher until proven otherwise? I once

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