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Defining epigenetic reprogramming, cellular reprogramming & rejuvenation

September 20, 2023 September 20, 2023 / By Professor Paul Knoepfler, Ph.D. / Leave a Comment

Epigenetic reprogramming is a term used in cell biology that is increasingly ending up in news stories too. Unfortunately, some folks, especially in the cellular rejuvenation and anti-aging space, are getting this term and other things confused. Just to start off, epigenetic reprogramming does not specifically mean cellular rejuvenation. The goal of today’s post is …

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Review of the new Zaret Cell paper on Myc & OSK in cellular reprogramming

November 29, 2012 February 1, 2021 / By Professor Paul Knoepfler, Ph.D.

There’s a new paper out this week in Cell from the Zaret lab that is very exciting. In this manuscript, Facilitators and Impediments of the Pluripotency Reprogramming Factors’ Initial Engagement with the Genome, Zaret’s team explores how Myc and Oct4, Sox2, and Klf4 (OSK) behave at the genomic level during cellular reprogramming. What are the most …

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Perspectives on David Sinclair anti-aging Cell pub & in vivo reprogramming

February 7, 2023 February 9, 2023 / By Professor Paul Knoepfler, Ph.D. / 2 Comments

About twenty years ago a science story made big news of a so-called anti-aging Methuselah gene. Methuselah gene and anti-aging The claim was that this DNA conferred long life on people. Hence the name Methuselah, which refers to a man from the Bible who reportedly lived 969 years. The so-called Methuselah gene was at first not a …

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All about Altos Labs & its $3B cellular rejuvenation push

January 20, 2022 August 21, 2023 / By Professor Paul Knoepfler, Ph.D. / 2 Comments

I wrote briefly a few months ago about Altos Labs. It’s a new kind of biotech institute that is focused on cellular reprogramming. Now we know much more and it’s clear this is a huge deal. What’s in this article What is Altos Labs? | Cellular rejuvenation | Reprogramming oldness | Challenges | Altos Strategies | Analysis of …

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Recent stem cell pubs & news: reprogramming, chromatin, single-cell, Astellas, & more

February 18, 2019 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / Leave a Comment

What new papers and news in the stem cell sphere caught your eye? Here are some recent items that seem notable to me. Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells. This paper reports cellular reprogramming to insulin-producing cells in mice. They reprogrammed α-cells with Pdx1 and MafA proteins. ‘Mitophagy inhibits amyloid-β and tau pathology and reverses …

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Fuzzy New Stem Cells Bring Reprogramming into Focus

December 10, 2014 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 2 Comments

How cool is it that literally fuzzy new stem cells called “F-class cells” bring substantial new sharp focus to the cellular reprograming arena? Remember Project Grandiose led by the great stem cell scientist Andras Nagy? It’s a massive project intended to decipher what makes stem cells tick and how ordinary cells be changed or reprogrammed into powerful …

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Sherley patent for reprogramming method like STAP cells

June 26, 2014 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 7 Comments

A new patent has been awarded to James Sherley for a very unusual method claimed for making induced pluripotent stem (iPS) cells. The patent, No. 8,759,098, claims that a single non-genetic chemical agent, xanthine, can by itself reprogram adult stem cells (ASC) into iPS cells (aka iPSCs; see image they released at left). Surprising patent, huh? Another …

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Cool Cell Stem Cell Paper From Ishii Team on Histones & Reprogramming

March 6, 2014 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 1 Comment

Two of my favorite things are stem cells and histones. When they both come together in one paper and it’s in my favorite journal, Cell Stem Cell, you’ve got my full attention. My own lab is especially interested in the roles of histones and Myc in stem cells. So when I saw a paper a paper from …

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Jacob Hanna on Radically Deterministic Reprogramming @TMM2013

October 23, 2013 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 2 Comments

What is “radically deterministic” cellular reprogramming? Jacob Hanna’s lab recently published a very high profile Nature paper on nearly 100% efficient iPS cell formation based on targeting a factor called Mbd3. This super efficiency is a major departure from past reported efficiencies. This morning here at the Till & McCulloch Stem Cell Meeting in Banff, …

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