Search Results for: cellular reprogramming

Text mining Cell Stem Cell: surprising insights into the journal

Cell Stem Cell was the winner of my 2011 best stem cell journal award (see 2011 awards here, 2012 awards will be announced in early January). As I’ve “complained” in the past, the only thing I wish would be different is they’d publish even more articles per issue or per month! But what exactly does Cell

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iPS cells are similar to cancer cells: part 1 of discussion of new paper

My lab just published a somewhat provocative paper (still in unproofed form at this point) arguing that iPS cells are very similar in some ways to cancer cells. How did we get to that conclusion (discussed in this post today, part 1 of the story) and what’s the back story on this paper (discussed in a later

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Jaenisch’s 5 key action items for the ES and iPS cell field

This morning on day two of the World Stem Cell Summit here in Pasadena, Rudy Jaenisch of the Whitehead Institute gave the scientific keynote address. It was a fabulous talk. Jaenisch, accurately described by Bernie Siegel as a true giant of the stem cell field, outlined the key issues facing the field of highly pluripotent

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Secret Not so Secret Recipe for Safer iPS cells

IPS cells, induced pluripotent stem cells, Knoepfler lab, stained for TRA-1-60, an ES cell marker., where do stem cells come from?

Just how tumorigenic are iPS cells?  The field really doesn’t know at this point. However, a steady stream of papers have raised red flag after red flag about genomic and epigenomic alterations/mutations that are linked to cancer. Of course, then there is the fact that all the genetic changes actually used to make reprogrammed cells

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The Inside Scoop on iPS cells early in 2011

It’s been more than 4 years since Shinya Yamanaka published the remarkable finding that his lab could transform or “reprogram” regular cells called fibroblasts into a very unique state that was quite similar to that of embryonic stem cells (ESC).  Yamanaka called these new cells “iPS cells” for induced pluripotent stem cells. Since that time,

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