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Patient’s Powerful Story on Multiple sclerosis and Getting Experimental Stem Cells

April 2, 2018 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 16 Comments

Multiple sclerosis (MS) can be an extremely debilitating disease that ultimately is fatal in some patients and reduces life expectancy and quality overall substantially. An MS patient named Caroline Wyatt, who works at the BBC, had the courage to open up in full detail on the BBC about having MS, her experience getting an experimental …

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Landmark New Stem Cell Trial for Multiple Sclerosis Raises Hopes

January 29, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 51 Comments

A new stem cell clinical trial for Multiple Sclerosis (MS) in Canada is raising hopes amongst patients and researchers. According to the Ottawa Citizen, the trial will be led by Dr. Mark S. Freedman (pictured, photo from Ottawa Hospital), director of the multiple sclerosis research unit at The Ottawa Hospital and “The Canadian trials which …

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A no B.S. guide to stem cells for Multiple Sclerosis (MS)

July 22, 2013 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 30 Comments

Today’s post is my no-B.S. guide to the possibility of stem cells being used to treat Multiple Sclerosis (MS). There is a great deal of buzz about using stem cells to treat or even cure multiple sclerosis. How much of this stem cell buzz is real hope and how much is hype? MS has a …

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ACT patent filing for MSCs: of Dancing Mice & Multiple Sclerosis

June 19, 2013 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 16 Comments

Is Advanced Cell Technology (ACT) on the road to cure Multiple Sclerosis (MS) using stem cells and specifically MSCs? Some folks seem to think it’s quite possible, but I remain skeptical. Still there have been some interesting developments. ACT has a relatively new patent filing for a mesenchymal stromal cell (MSC) product that was just …

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Stem cell treatments for multiple sclerosis: where do things stand?

August 14, 2012 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 3 Comments

Where do things stand on the potential of stem cell treatments for multiple sclerosis (MS)? MS is an often devastating autoimmune disease in which the immune system attacks its own nervous system. More info can be found at the National MS website here. MS is a very serious health problem globally as about 400,000 people …

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Weekly reads: Vertex, stem cells for MS, Athersys, 900-day paper review at Nature

March 3, 2024 March 2, 2024 / By Professor Paul Knoepfler, Ph.D. / 1 Comment

“While still early, these results support the continued progression of our VX-880 clinical studies, as well as future studies using our encapsulated islet cells, which hold the potential to be used without the need for immunosuppression,” said Bastiano Sanna, Ph.D., executive vice president and chief of cell and genetic therapies at Vertex.

Vertex Pharmaceuticals has a lot going for it right now on the cell therapy front. For instance, they have the strongest type 1 diabetes cell therapy pipeline after some recent acquisitions. Still it’s not a simple matter to succeed in the cell therapy space even with one therapy for one targeted disease. Trials are tough …

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Weekly reads: Vertex & CRISPR Therapeutics, Arnold Caplan death, MS genetics

January 14, 2024 January 14, 2024 / By Professor Paul Knoepfler, Ph.D. / 5 Comments

The biotechs Vertex and CRISPR Therapeutics have an interesting relationship as biotechs. They are partners are multiple levels but also are very different as companies including in size. There’s been a key development in one of their partnerships. Before we jump into that, please check out the video version of my 20 stem cell and …

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Weekly reads: stem cells for MS, good news x2, extending dog years, Neuralink updates

December 3, 2023 December 2, 2023 / By Professor Paul Knoepfler, Ph.D. / 2 Comments

For about as long as I’ve been writing The Niche, people have been asking about stem cells for MS. There’s a huge need for new therapies. While a chemo-based approach with autologous hematopoietic stem cell transplantation (HSCT) looks to work for certain cases of multiple sclerosis (although not yet approved in the US), other cell …

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Weekly reads: stem cells for MS, Kimera Labs IND, FDA lawsuit

October 1, 2023 September 30, 2023 / By Professor Paul Knoepfler, Ph.D. / 10 Comments

There has been a steady stream of encouraging data on stem cells for MS. Particularly for certain kinds of MS. A new study adds to this upbeat direction. Good news on stem cells for MS Haematopoietic stem cell transplantation for treatment of relapsing-remitting multiple sclerosis in Sweden: an observational cohort study, Journal of Neurology, Neurosurgery, …

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Weekly reads: stem cell cost, trial death, HSCT for MS, Neuralink

May 28, 2023 May 27, 2023 / By Professor Paul Knoepfler, Ph.D. / Leave a Comment

So many things have gotten very expensive these days that it got me thinking this past week again about stem cell cost. For this reason, I’ve been running polls asking people what they’ve paid for stem cells and how many therapies they’ve gotten. Before jumping into our weekly reads, check out those running polls on …

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