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Patient’s Powerful Story on Multiple sclerosis and Getting Experimental Stem Cells

April 2, 2018 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 16 Comments

Multiple sclerosis (MS) can be an extremely debilitating disease that ultimately is fatal in some patients and reduces life expectancy and quality overall substantially. An MS patient named Caroline Wyatt, who works at the BBC, had the courage to open up in full detail on the BBC about having MS, her experience getting an experimental …

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Landmark New Stem Cell Trial for Multiple Sclerosis Raises Hopes

January 29, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 51 Comments

A new stem cell clinical trial for Multiple Sclerosis (MS) in Canada is raising hopes amongst patients and researchers. According to the Ottawa Citizen, the trial will be led by Dr. Mark S. Freedman (pictured, photo from Ottawa Hospital), director of the multiple sclerosis research unit at The Ottawa Hospital and “The Canadian trials which …

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A no B.S. guide to stem cells for Multiple Sclerosis (MS)

July 22, 2013 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 30 Comments

Today’s post is my no-B.S. guide to the possibility of stem cells being used to treat Multiple Sclerosis (MS). There is a great deal of buzz about using stem cells to treat or even cure multiple sclerosis. How much of this stem cell buzz is real hope and how much is hype? MS has a …

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ACT patent filing for MSCs: of Dancing Mice & Multiple Sclerosis

June 19, 2013 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 16 Comments

Is Advanced Cell Technology (ACT) on the road to cure Multiple Sclerosis (MS) using stem cells and specifically MSCs? Some folks seem to think it’s quite possible, but I remain skeptical. Still there have been some interesting developments. ACT has a relatively new patent filing for a mesenchymal stromal cell (MSC) product that was just …

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Stem cell treatments for multiple sclerosis: where do things stand?

August 14, 2012 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 3 Comments

Where do things stand on the potential of stem cell treatments for multiple sclerosis (MS)? MS is an often devastating autoimmune disease in which the immune system attacks its own nervous system. More info can be found at the National MS website here. MS is a very serious health problem globally as about 400,000 people …

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Weekly reads: stem cells for MS, Kimera Labs IND, FDA lawsuit

October 1, 2023 September 30, 2023 / By Professor Paul Knoepfler, Ph.D. / 10 Comments

There has been a steady stream of encouraging data on stem cells for MS. Particularly for certain kinds of MS. A new study adds to this upbeat direction. Good news on stem cells for MS Haematopoietic stem cell transplantation for treatment of relapsing-remitting multiple sclerosis in Sweden: an observational cohort study, Journal of Neurology, Neurosurgery, …

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Weekly reads: stem cell cost, trial death, HSCT for MS, Neuralink

May 28, 2023 May 27, 2023 / By Professor Paul Knoepfler, Ph.D. / Leave a Comment

So many things have gotten very expensive these days that it got me thinking this past week again about stem cell cost. For this reason, I’ve been running polls asking people what they’ve paid for stem cells and how many therapies they’ve gotten. Before jumping into our weekly reads, check out those running polls on …

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Weekly reads: gene therapy nod, Nature pub ethics, CRISPR LDL

May 21, 2023 May 20, 2023 / By Professor Paul Knoepfler, Ph.D. / Leave a Comment

Multipotent & totipotent vs pluripotent stem cells, very early human embryos totipotent stem cells

Totipotency literally means all powerful, but it refers in biology to specific cells. These cells can make every type of cell in the body of an organism plus the extraembryonic tissues needed for development. This includes humans. So if you could reprogram human cells like blood or skin cells into totipotent stem cells, you might …

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Where Kimera Labs fits into sphere of exosome companies

March 16, 2023 March 16, 2023 / By Professor Paul Knoepfler, Ph.D. / 4 Comments

Today’s post takes a close look at the exosome manufacturer Kimera Labs in the context of the main exosome companies. What are exosomes? Exosomes are microscopic bubbles or vesicles produced by cells. Exosomes contain many cellular substances that are biologically active. Some of these materials may be helpful clinically, while others could pose risks. Clinical outcomes …

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Weekly reads: reprogramming aging, astrocytes, cartilage, ChatGPT

January 15, 2023 January 30, 2023 / By Professor Paul Knoepfler, Ph.D. / Leave a Comment

Let’s start with a couple of new pieces on in vivo reprogramming. The idea here is to do something like making iPS cells but doing it inside organisms and not quite pushing cells all the way back to pluripotency. Just younger, healthier cells. Why do that? The goal is to achieve a kind of anti-aging …

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