Search Results for: weekly reads

Weekly reads: FDA modernization, TFs on the brain, mortality timer, pluripotent trials

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FDA

How will things change at the FDA under the second Trump Administration? It’s a key question for our field but not easy to answer. Most likely there will be more instability at the agency. Some leaders, like of CDER, have already left. in my overall regenerative medicine predictions for 2025, I’ve included more predictions about […]

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Weekly reads: grow a spine, China clears MSCs, Denise Richards, stem cell soups

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Notochord, growing a spine.

If you tell a scientist that they should be growing a spine, they might take you literally. For instance, if you say this because you want a scientist to show some courage and speak out about something difficult, instead they might try to make an actual human spine in a lab. We’ll start there this

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Weekly reads: stem cell therapies that work, exosomes, H3.3 K27M, Joe Rogan

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stem cell therapy

How close are we to having new stem cell therapies that work? The field is nearly there on several fronts, but we shouldn’t get ahead of ourselves. Last week I noted the “soon” in a Nature News headline “Stem cells head to the clinic: treatments for cancer, diabetes and Parkinson’s disease could soon be here.”

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Weekly reads: intermittent fasting and stem cells, vet warning, blastemas

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intermittent fasting and stem cells

Intermittent fasting must be good for stem cells, right? It’s not so clear. Like many things in biology, intermittent fasting can have seemingly opposite effects. Before we get into that, the news of the week is that the FDA approved Mesoblast’s Ryoncil MSC drug for some cases of pediatric GvHD. This has sparked lively discussion.

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Weekly reads: aging cells, scientists relying on ChatGPT, anemone stem cells

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cellular aging

Do our aging cells necessitate that we age overall as people? Flipping it around, if we can stop or reverse enough cellular aging, will our overall aging be positively affected? It’s clear that people age very differently from each other and so do our cells and organs. Interestingly, intramurally in a sense the cells and

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Weekly reads: Scott Gottlieb v. RFK Jr., DNA typewriters, Arnold Caplan

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Peter-Marks-Scott-Gottlieb-FDA

Remember former Trump’s FDA Commissioner Scott Gottlieb? Gottlieb’s back in the news in an interesting way related to the upcoming second Trump administration. I just wrote about what to expect from new FDA Commissioner nominee Marty Makary. In that piece, I noted that Scott Gottlieb first came to lead the FDA after a record of

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Weekly reads: GIOSTAR stem cell clinic IND, cadaver marrow, NIH under Trump 2.0, tweets from a stem cell

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Giostar

What happens if unproven stem cell clinic firms like GIOSTAR start getting okays from the FDA to do clinical trials? On the one hand, it could reflect a positive trend of stem cell clinic firms working with the FDA and toward compliance. Having more robust data. However, I worry about some of these types of

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Weekly reads: stem cell therapy for vision loss, cancer self-experimentation, Slovenia, 14-day rule

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limbal stem cell deficiency LSCD, stem cell therapy for vision loss

Is there a proven stem cell therapy for vision loss? When I started The Niche back in early 2010, one major area of hope was that there might one day be a stem cell therapy for vision loss or even blindness. Maybe even a cure for blindness. While we’re not there yet as a field,

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Weekly reads: cancer stem cells, encouraging findings, Trump & NIH, proteomics

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Liver cancer stem cells, cancer stem cells

Cancer stem cells are stem cell-like cells in many tumors that are key contributors to the ability of tumors to persist and recur after treatment. For those reasons, they are also thought to be major targets, including of emerging therapies. Data also suggest that some therapies may create new types of cancer stem cells leading

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