brain tumors

Reciprocal CRISPR gene editing in pediatric glioma: defining mechanisms & testing drugs

reciprocal-CRISPR-mutant-H3.3

My lab’s new paper in Communications Biology focused on high-grade pediatric glioma that have mutant histone variant H3.3 and we did something fairly novel that we are calling reciprocal CRISPR. Kids with these tumors have a near zero survival rate within a few years of diagnosis so we as a field desperately need something new to give …

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OCT4-SOX DNA dance, PRC2, a noisy competition & more cell weekly reads

EMBO-J-2020-Fig-3b-Salazar-Roa-et-al

What’s new in the stem cell, cell therapy, and regenerative medicine world as well as biomedical science more generally including cancer? There’s quite a bit of news as reflected in media pieces and new pubs. Today’s post is focused on pubs that just came out. For last week’s recommended reads see here. Oct4-Sox2 Nucleosome Binding …

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How can baldness help cure kid’s cancer? St. Baldrick’s

St.-Baldricks

For the 4th straight year I’m going to get my head shaved to support St. Baldrick’s in their mission to cure childhood cancer. St. Baldrick’s is a great charity that raises money specifically for pediatric cancer research in part via events at which “shavees” raise funds via pledges that they will get their heads shaved. …

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Are glioma stem cells a path to better outcomes?

Glioblastoma

Glioblastoma and other related malignant glioma tumors including diffuse intrinsic pontine glioma (DIPG) are some of the most devastating of all human cancers, and glioma stem cells may contribute to the lethality. You can see an image of a glioma (the white area in the brain scan) from Wikipedia above. These brain tumors usually kill …

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