January 22, 2021

The Niche

Trusted stem cell blog & resources

brain tumors

3 min read

My lab’s new paper in Communications Biology focused on high-grade pediatric glioma that have mutant histone variant H3.3 and we did something fairly novel that we are calling reciprocal CRISPR. Kids with these tumors have a near zero survival rate within a few years of diagnosis so we as a field desperately need something new to give them and their families real hope. Our paper is entitled, “Reciprocal H3.3 gene editing identifies K27M and G34R mechanisms in pediatric glioma including NOTCH signaling.” What we did in …Read More

4 min read

What’s new in the stem cell, cell therapy, and regenerative medicine world as well as biomedical science more generally including cancer? There’s quite a bit of news as reflected in media pieces and new pubs. Today’s post is focused on pubs that just came out. For last week’s recommended reads see here. Oct4-Sox2 Nucleosome Binding & Impact in mESCs This is one of my favorite papers of 2020 so far, coming to us from Science. Mechanisms of OCT4-SOX2 motif readout on nucleosomes. I knew from …Read More

1 min read

For the 4th straight year I’m going to get my head shaved to support St. Baldrick’s in their mission to cure childhood cancer. St. Baldrick’s is a great charity that raises money specifically for pediatric cancer research in part via events at which “shavees” raise funds via pledges that they will get their heads shaved. Children facing a cancer diagnosis not only have to deal with that reality of having cancer, but also often face side effects from their treatments such as chemo and …Read More

2 min read

Glioblastoma and other related malignant glioma tumors including diffuse intrinsic pontine glioma (DIPG) are some of the most devastating of all human cancers, and glioma stem cells may contribute to the lethality. You can see an image of a glioma (the white area in the brain scan) from Wikipedia above. These brain tumors usually kill the people who get them within 1-2 years even with treatments and because today’s therapies for these cancers are themselves extremely harsh, patients’ quality of life is often very …Read More