October 28, 2020

The Niche

Knoepfler lab stem cell blog

cloning

2 min read

What is morally acceptable and where do we draw the line at behaviors that might just go too far such as human reproductive cloning? Over the years American attitudes have shifted on a number of potentially hot button moral behaviors including reproductive human cloning and pollsters including Gallup have tracked these attitudes. Gallup just came out with a poll suggesting that Americans are shifting, at least relatively speaking, toward being more morally accepting of some controversial behaviors. For example, the percent of Americans who view …Read More

1 min read

I’ve been thinking a lot lately about how the future of human reproduction might be very different from today’s reality due to recent technological advances including cloning. Things like human cloning (the reproductive, “Star Wars” kind) and human genetic modification seem very real now. It feels almost imminent in a sense compared to the milleenia of the “old fashioned” natural way of making babies. I find this technology both fascinating as a scientist and also mind-blowing as a science writer. In fact, I’ve become so …Read More

4 min read

Just how good are human embryonic stem (ES) cells made by therapeutic cloning via nuclear transfer, with the successful technique first reported by the lab of Shoukhrat Mitalipov at OHSU last year? How do they compare to induced pluripotent stem (iPS) cells or traditional ES cells made from IVF embryos? A new paper in Nature directly tackles these key questions, but first a bit of context. Three separate groups have now successfully made ES cells using somatic cell nuclear transfer (SCNT). I have reviewed those three therapeutic cloning papers …Read More

4 min read

It was intriguing last week to read about another advance in somatic cell nuclear transfer (SCNT)-based therapeutic cloning of human embryonic stem cells (hESC). The first such work was published last year by Mitalipov’s group from OHSU. This second paper to produce so-called nuclear transfer hESC (NT-hESC) made the important advance to show that it could be done using adult and even old human somatic cells. This is a reproducible technology, which is very important. However, key challenges and concerns remain for human therapeutic cloning …Read More