September 28, 2020

The Niche

Knoepfler lab stem cell blog

CRISPR babies

3 min read

Something called, “The International Commission on the Clinical Use of Human Germline Genome Editing” has issued a new report on heritable human genome editing (HHGE). The Commission was convened by the U.S. National Academy of Medicine, the U.S. National Academy of Sciences, and the U.K.’s Royal Society. This post is my initial take on the summary of the lengthy report. I hope to have time to read the full report in coming weeks and it’s possible some new perspectives may emerge. Here is my thinking as …Read More

4 min read

Another week and more great papers and interesting news in the regenerative medicine sphere including COVID-19 updates, stem cells for vision, and more. Rebuilding Corneas With Stem Cells Stem cell-based regenerative medicine arguably has shown the most promise for vision loss. A PR from Massachusetts Eye and Ear says: Doctors rebuild damaged corneas using patients’ own own stem cells for first time in US. This is interesting work. The autologous transplant method is called “‘cultivated autologous limbal epithelial cell transplantation’ (CALEC).” It involves taking …Read More

6 min read

Three new studies reported in preprints all show severe DNA damage to human embryos from CRISPR a surprisingly high percentage of the time including in some cases loss of heterozygosity (LOH). Anywhere from about a quarter to half of CRISPR’d embryos exhibited major genome damage. As readers of The Niche know, I never was a fan of the idea of doing CRISPR on human embryos for reproductive use, although I have been supportive of limited, thoughtful in vitro gene-editing studies on human embryos. The …Read More

7 min read

Making a CRISPR baby is a controversial idea to even propose now for many reasons, yet even after He Jiankui’s train wreck some people have seemed eager to try it including apparently a scientist whose name perhaps many readers here are not so familiar with in this context: Professor Hui Yang. ‘CRISPR baby guys’ Is it really a good time to be pushing CRISPR babies? The original “CRISPR baby guy” He Jiankui was recently sentenced to three years in prison for a variety of actions …Read More