August 8, 2020

The Niche

Knoepfler lab stem cell blog

designer babies

7 min read

Making a CRISPR baby is a controversial idea to even propose now for many reasons, yet even after He Jiankui’s train wreck some people have seemed eager to try it including apparently a scientist whose name perhaps many readers here are not so familiar with in this context: Professor Hui Yang. ‘CRISPR baby guys’ Is it really a good time to be pushing CRISPR babies? The original “CRISPR baby guy” He Jiankui was recently sentenced to three years in prison for a variety of actions …Read More

2 min read

Here in the U.S. we just had our big Thanksgiving holiday, but science goes, stem cells keep growing and needing attention, and it’s another weekend chance to catch up on our paper reading. Here’s this weekend edition of recommended reads including news items and pubs. From Cell Stem Cell: Single-Cell Transcriptome Analysis of Uniparental Embryos Reveals Parent-of-Origin Effects on Human Preimplantation Development. and another there on stem cell machinery in cancer: Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy. …Read More

6 min read

By Guillaume Levrier Human germline editing has been done before. It will be done again in the future, as it is relatively easy to perform. No mechanism with the de facto ability to prevent it from being organized has yet been designed, let alone implemented. But the fact that germline editing has, can, and will happen again does not deprive anyone of their right to have an opinion on this capacity. The CRISPR Consensus symposium (see video below) set up at the Innovative Genomics Institutes …Read More

4 min read

A Russian Scientist named Denis Rebrikov told Nature and then other media including NPR last week that he plans to make CRISPR babies. In other words, babies with heritable genetic modifications. I don’t doubt that Rebrikov (pictured in ResearchGate image) might want to do this nor that he might try it, but rather I’m writing this post to point out how his statements including about why it’d supposedly be a good idea don’t withstand much scrutiny. What has Rebrikov said about his plan and …Read More