mitochondrial disease

Early encouraging mitochondrial donation study produced 8 babies but long road ahead

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mitochondrial donation

A new reproductive method called mitochondrial donation has reached a milestone. The goal of this approach is to prevent mitochondrial diseases in children whose mothers have disease-associated mitochondrial DNA. Two linked NEJM papers on report encouraging results in humans from the innovative approach. The first small paper reported on this first-of-its-kind mitochondrial donation study, focusing […]

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Mitochondrial Replacement Hype Goes Nuclear Including by Wellcome Trust

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A new paper from a UK team yesterday showed that mitochondrial replacement therapy faces a serious and difficult safety hurdle fitting with similar findings from an earlier recent study from a different team led by Dieter Egli, but the UK media and some scientists there are engaging in hype, claiming the exact opposite. They are pushing the unscientific

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New Herbert lab Nature paper reinforces mitochondrial replacement Achilles heel

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Today a new Nature paper from Dr. Mary Herbert’s group in the UK has found a key problem with mitochondrial replacement therapy that fits with data from others. Mitochondrial replacement data The goal of preventing mitochondrial disease using various kinds of genome transfer technologies is a noble one, but mitochondrial replacement therapy has faced a

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UK should freeze mitochondrial replacement as Egli paper ID’s serious problem

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Egli-genetic-drift-paper

An important new Cell Stem Cell paper from Dieter Egli’s lab points to an inherent, serious problem with so-called 3-person IVF or mitochondrial replacement technology that warrants putting an immediate hold on all efforts to use it in humans. I have pasted the graphical abstract from the paper below. For years a few of us scientists and

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New Mitalipov paper on stem cell mitochondria: challenge for IPS cell field?

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Mitalipov-mitochondrial-mutations

A new paper from Shoukhrat Mitalipov’s lab on stem cell mitochondria points to a pattern whereby induced pluripotent stem (IPS) cells tend to have more problems if they are from older patients. New Mitalipov paper What does this paper mean for the stem cell field and could it impact more specifically the clinical applications of IPS

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Monday, March 2: My Reddit AMA on 3-Person IVF, Mitochondrial Transfer

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reddit-logo

On Monday, I’ll be doing another Reddit AMA, this time on 3-person IVF also known as 3-parent IVF, mitochondrial transfer, 3-parent babies, etc. You can see the upcoming AMAs including mine listed in the right sidebar here. Mine will start at 10AM PST/1PM EST. I hope to discuss with a wide audience all the key

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Nature Biased News Coverage of 3-Person IVF

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NatureNews is a science news outlet so I’ve been wondering what the heck the deal is with their strongly biased news coverage of the mitochondrial transfer 3-person IVF technology debate. By way of context, I like NatureNews and am a regular reader, but their coverage of the mitochondrial transfer debate has been completely one-sided and inaccurate. Their

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