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Weekly reads: Gamida Cell, Siddhartha Mukherjee, CRISPR in viruses

Abigail L. Jenkins, Gamida Cell

Hematopoietic stem cells have many clinical applications and a company called Gamida Cell has an interesting product in this area called Omidubicel that may have several applications.  I’m going to start the weekly reads with news there. Gamida Cell and the FDA A recent piece discussed how Omidubicel is progressing with the FDA. FDA extends […]

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Updates on CRISPR therapy development and clinical trials

When I first heard of CRISPR gene editing I was excited for my lab to try it out, but it seemed a long way from the field having even one CRISPR therapy available to treat human disease. In the Knoepfler lab, we study genetic and genomic programming in human development and disease. Gene editing seemed

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What is Mastodon & why so far it’s a clunky alternative to Twitter

Mastodon

Lately it seems like something called Mastodon is on the minds of many a Twitter user. There is a wave of people tweeting “let’s dump Twitter and go to Mastodon now that Musk has taken over!” However, so far I don’t see Mastodon as a solid alternative to the admittedly annoyingly musky Twitter. I do

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Weekly reads: death in CRISPR trial, sickle cell, nose picking & dementia, epilepsy

CRISPR gene editing

As both a scientist who works on stem cells, cancer, and CRISPR, and a research advocate I’ve been fortunate to meet many patient advocates over the years. Some have been participants in clinical trials themselves. Benefits & risks of clinical trial participation It is very sobering to find out that a clinical trial participant has

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Weekly reads: KRAS G12C, eLife journal controversy, bird iPSCs

KRAS mutations, KRAS G12C

If you’ve never heard of the KRAS G12C mutation, it’s a particularly frightening mutation present in numerous cancers. Like the MYC oncogene, many people view mutations in RAS as undruggable, but new efforts show some glimmers of hope. The drug Sotorasib has been approved by the FDA to target the KRAS G12C mutation. Here’s a

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Weekly reads: NAM dubs 3 stem cell researchers, kick the 2 buckets, stem cell homing

Sally Temple, stem cell researchers

The National Academy of Medicine elected a cohort of new members including three stem cell researchers. It’s great to see our field and these great scientists get recognition. The new NAM stem cell researchers include Sally Temple, Connie Eaves, and Tippie MacKenzie. Here’s a little bit about each of them. Dr. Temple is a stem cell biologist

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Germ or sex cells: DNA content, research, clinical applications

sex cells, haploid, diploid, germ cells

Germ or sex cells have many important implications for health and research. In today’s post the goal is to provide a helpful, comprehensive overview of these remarkable cells. Where does research on these cells stand today? It’s an exciting time. What are sex cells?  | Are sex cells haploid or diploid?  | Why are germ cells

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Digging into the multiple ways to get stem cells

multiple ways to get stem cells

I get great questions from readers of The Niche including, “Are there multiple ways to get stem cells?” The answer is “yes.” Why is this important? The different sources of stem cells can impact both their use in basic research and their potential clinically. My goal in today’s post is to give an overview of

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Weekly stem cell reads: bat stem cells, brainier organoids, more

bat stem cell

I’m working to send out a big grant on Tuesday so I’m busier than ever but a few stem cell and regenerative medicine stories caught my eye. I can’t write grants 24/7 without a few breaks although sometimes it feels like that’s what I’m doing. Bat stem cell derivation Pluripotent bat stem cells as a

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