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Northwestern abruptly ending Burt HSCT autoimmune trials

August 29, 2019 / Professor Paul Knoepfler, Ph.D. / 55 Comments

“HSCT Chicago Clinic Closing!” is the startling header in all caps on a patient-run Facebook page about a stem cell therapy clinical trial program at Northwestern University. What’s going on? Unfortunately, the promising field of hematopoietic stem cell transplantation (HSCT) for multiple sclerosis (MS) and other autoimmune diseases seems to have suffered an unexpected setback […]

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Magenta Therapeutics Good News-Bad News Trial Data

November 4, 2018 / Professor Paul Knoepfler, Ph.D. / 2 Comments

Magenta Therapeutics is a biotech company with a portfolio including stem cell products. Their most well known investigational drug product is an expanded umbilical cord stem cell product called MGTA-456, an “ex-Novartis” product. Magenta just released new trial data on MGTA-456, which I see as a case of good news-bad news, and investors seem to

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Cynata approval for 1st ever allo trial of IPSC-derived MSCs for GVHD

September 22, 2016 / Professor Paul Knoepfler, Ph.D. / 6 Comments

Cynata Therapeutics Limited has received approval from UK regulators to start a first-of-its-kind allogeneic IPSC-based trial of MSCs for graft versus host disease (GVHD). Cynata also had some big news a couple weeks back with a deal with Fujifilm. The company is aiming to recruit 16 patients to test whether the MSCs (a type of adult

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Masayo Takahashi (高橋政代) on IPSC Trial for Vision

July 7, 2015 / Professor Paul Knoepfler, Ph.D. / 9 Comments

Masayo Takahashi (高橋政代) on IPSC Trial for Macular Degeneration By Michael Cea Stem Cell Analyst & Advocate (editor’s note: piece was originally posted on Michael’s blog here; follow Michael on Twitter @msemporda) Masayo Takahashi interview Having followed closely the developments in programs using pluripotent based therapeutics I was fortunate during ISSCR2015 to have the opportunity to

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Reactions to RIKEN’s STAP cell protocol

March 5, 2014 / Professor Paul Knoepfler, Ph.D. / 78 Comments

A small group of the STAP authors via RIKEN have now released a detailed protocol also available at Nature Protocol Exchange for making STAP stem cells entitled “Essential technical tips for STAP cell conversion culture from somatic cells”. This comes about 5 weeks after publication of their Nature STAP stem cell papers. 2020 update: With the 4th and

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سلولهای بنیادی چه هستند؟

June 6, 2011 / Professor Paul Knoepfler, Ph.D. / 14 Comments

Note that this is one of our “Stem Cells Not Lost in Translation” series. You can see the full series of our stem cell white paper in 34 languages here. مترجم : یاسمن نیکنام سلولهای بنیادی چه هستند؟ بدن انسان دارای صدها نوع مختلف سلول است که برای سلامت روزانه ما مهم هستند. این سلولها

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Disease Focus Series: Cancer

October 26, 2010 / Professor Paul Knoepfler, Ph.D.

Cancer is a class of diseases that are intimately linked to stem cells. In fact, I would go so far as to call some types of cancer cells and stem cells, cousins. This concept, of a tight relationship between stem and cancer cells, is under intense investigation but at the same time it is something

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