Search Results for: PGD

Why Mitalipov’s ‘magic’ room for human embryo CRISPR may give us pause

/ / 7 Comments
Shoukhrat-Mitalipov

The debate over whether the main conclusions of the Nature paper on human embryo CRISPR led by Shoukhrat Mitalipov’s lab at Oregon Health Sciences University (OHSU) are correct remains unresolved. Note that Nature just added an editorial alert just above the references section to their paper: “Updated online 02 October 2017. Editorial Note: Readers are alerted that some […]

Why Mitalipov’s ‘magic’ room for human embryo CRISPR may give us pause Read More »

4 key reasons Mitalipov paper doesn’t herald safe CRISPR human genetic modification

/ / 2 Comments
CRISPR-dart-board

We can be confident that human genetic modification via CRISPR’ing of embryos soon will be safe and effective after that new exciting Mitalipov team paper, right? Wrong. The reality is far more complicated and interesting on the tech side. In a nutshell, I see the paper as a significant scientific, but not necessarily medical advance.

4 key reasons Mitalipov paper doesn’t herald safe CRISPR human genetic modification Read More »

Review of Mitalipov paper CRISPR’ing human embryos: transformative work on the edge

/ / 3 Comments
Human-embryo-CRISPR

In the same way perhaps that some excited relatives or parents-to-be both gush and worry about a baby before it is even born, our field has been transfixed for a week by the Mitalipov paper on CRISPR’ing human embryos even though the paper just now came out. Now that the paper is out, we can

Review of Mitalipov paper CRISPR’ing human embryos: transformative work on the edge Read More »

In first for U.S., Mitalipov reportedly CRISPR’d human embryos & it was great

/ / 3 Comments
Early-human-embryos

More CRISPR’d human embryos, but this time in America? MIT Tech Review is reporting that Oregon scientist Shoukhrat Mitalipov has used CRISPR on human embryos in his lab in the US. Apparently a paper is in the works on this. While details are sketchy and some specifics remain to be clarified to be sure of

In first for U.S., Mitalipov reportedly CRISPR’d human embryos & it was great Read More »

Human embryo CRISPR pub includes plagiarism: the victim’s unique account

/ / 5 Comments
Plagiarism

Cut, modify, paste… It’s kind of a CRISPR mantra for those of us using gene editing in the lab. But it’s supposed to be happening just on DNA, right? Now it appears that someone on a team of human embryo CRISPR researchers possibly got carried away with the cutting-modifying-pasting mindset to take it beyond DNA to also do

Human embryo CRISPR pub includes plagiarism: the victim’s unique account Read More »

Paper on 1st use of CRISPR in normal human embryos: problems remain

/ / 1 Comment
CRISPR-human-embryo-Tang-et-al

The first report of the use of CRISPR gene editing in normal human embryos was published today as a short paper from a team in China. There have been rumors for over a year that more CRISPR human embryo papers were coming including some using normal embryos. Here’s one and we can now expect more even

Paper on 1st use of CRISPR in normal human embryos: problems remain Read More »

Live blogging Future of Genome Medicine: great talks by Feng Zhang & others

/
Feng-Zhang-talk-e1488664593428

What is the future of Genome Medicine? The meeting by that same name that I’m at down here in La Jolla is all about tackling this question and the line up of speakers today on the first day is amazing. I’m speaking about IPS cells as a basis for personalized medicine tomorrow morning so that’s exciting.

Live blogging Future of Genome Medicine: great talks by Feng Zhang & others Read More »

National Academies panel leaves door a crack open to future human genetic modification

/ / 6 Comments
Early-human-embryos

A National Academies panel on human genome editing chaired by Alta Charo and Richard Hynes released its report today. While it covered both somatic and germline (heritable) human genetic modification, the latter topic is far more contentious. You can see the National Academies summary of their report here. You can read the full report here.

National Academies panel leaves door a crack open to future human genetic modification Read More »

New Herbert lab Nature paper reinforces mitochondrial replacement Achilles heel

/ / 1 Comment
Herbert-mitochondria-Nature-paper

Today a new Nature paper from Dr. Mary Herbert’s group in the UK has found a key problem with mitochondrial replacement therapy that fits with data from others. Mitochondrial replacement data The goal of preventing mitochondrial disease using various kinds of genome transfer technologies is a noble one, but mitochondrial replacement therapy has faced a

New Herbert lab Nature paper reinforces mitochondrial replacement Achilles heel Read More »

First anti-CRISPR political campaign is born in Europe

/ / 2 Comments
Stop-Baby-GM

Campaigns are underway in several European countries against the possible use of genetic modification in humans to make designer babies and one has a distinctly anti-CRISPR tone. For example, in France a group is pushing an anti-GM baby campaign and the same kind of thing is going on in Switzerland, which I blogged about recently. In

First anti-CRISPR political campaign is born in Europe Read More »