Search Results for: mitalipov

Mitalipov Nature pub review: IPSC & SCNT for mitochondrial disease

Mitalipov-IPSC-paper

In a new, thought-provoking paper today in Nature, Shoukhrat Mitalipov and a multi-institutional team report a significant advance toward potential novel ways to treat mitochondrial diseases. What are these illnesses? Mitochondrial diseases are rare, but devastating disorders caused by genetic mutations. Today they are largely impossible to treat in meaningful ways other than palliative care. Some …

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The Odd Couple of Cloning Research: Mitalipov & Woo Suk Hwang Unite

Hwang-Mitalipov

Remember that old TV show the Odd Couple with very proper Felix Unger and his polar opposite Oscar Madison who has all kinds of baggage? They’ve cloned it into a remake to be on TV soon here in the US in 2015. It seems only fitting then that actual human cloning research has a new …

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Review of Mitalipov Nature paper: cloned ES cells vs iPS cells

NT-ESC

Just how good are human embryonic stem (ES) cells made by therapeutic cloning via nuclear transfer, with the successful technique first reported by the lab of Shoukhrat Mitalipov at OHSU last year? How do they compare to induced pluripotent stem (iPS) cells or traditional ES cells made from IVF embryos? A new paper in Nature directly tackles these …

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Why Shoukhrat Mitalipov opposes human cloning

People have been confused about human cloning issues in the last few weeks on a number of levels. The confusion has come along with the excitement, concern, and increased interest in cloning lately since the lab of Dr. Shoukhrat Mitalipov reported a few weeks back in Cell the astonishing feat of successful human embryonic stem …

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CRISPR often damages human embryo chromosomes

human-embryo-modification

Three new studies reported in preprints all show severe DNA damage to human embryos from CRISPR a surprisingly high percentage of the time including in some cases loss of heterozygosity (LOH). Anywhere from about a quarter to half of CRISPR’d embryos exhibited major genome damage. As readers of The Niche know, I never was a …

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Counterpoints to Lovell-Badge & Daley’s CRISPR baby rationales

CRISPR-baby

Two prominent scientists, Robin Lovell-Badge and George Daley, have been amongst the most outspoken proponents of leaving the door open to heritable human genetic modification via CRISPR. While they each have articulated their reasons in somewhat different ways at times, their core reasons arguing in favor of future heritable CRISPR appear largely the same. In …

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Good final grades on my 20 x 2018 stem cell predictions

stem-cell-crystal-ball-300x3001

Each year I make a list of stem cell predictions for the following year and I’ll release my predictions for 2019 soon, but first I’m grading how my 20 predictions for 2018 turned out. It seems I did better than usual predicting what would happen this year. I only got a couple partial credit or …

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Mulling over latest CRISPR tumult, this one from Nat Biot pub on DNA lesions

CRISPR-dart-board

If it seems to you like dramatic cautionary tales about CRISPR accompanied by all sorts of media are coming at us more frequently, it’s not your imagination. In the latest yesterday, it was reported in a new paper led by Allan Bradley that CRISPR-Cas9 results in sometimes large-scale chromosomal lesions at or even away from the …

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Keep calm & CRISPR on: perspectives on report of human Cas9 immunity

Keep-calm-CRISPR-on

The news that CRISPR-Cas9 gene editing in its current form may not work in a substantial fraction of people due to many of us having immunity to Cas9 came as a shock to many, but if you think about it, maybe it’s not so surprising. I don’t see it as the end of the world. A (preprint) from …

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