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Adverse event in IPS cell (ips細胞) trial for vision loss in Japan: initial perspectives

January 16, 2018 December 22, 2023 / By Professor Paul Knoepfler, Ph.D. / 3 Comments

A team of researchers at RIKEN and Kobe City Medical Center reported at a press conference today a serious adverse event in a clinical trial participant receiving an induced pluripotent stem cell (IPS cell)-based therapy for vision loss. According to Japan Times and Yahoo! Japan (in Japanese), the patient in question in the IPS cell …

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Japan IPS cell trial for vision to start in new incarnation

February 11, 2017 December 22, 2023 / By Professor Paul Knoepfler, Ph.D. / 13 Comments

It’s been a long road, but the first ever IPS cell clinical study in humans is starting up again in a new incarnation. You might say it has been regenerated in a novel form. Masayo Takahashi (高橋政代) first started the pioneering IPS cell study a few years back in 2014, but it ended up …

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Samantha Yammine: Multiple filters for stem cell research at Canadian stem cell conference

November 1, 2016 December 22, 2023 / By Professor Paul Knoepfler, Ph.D.

By Samantha Yammine, PhD Candidate in Derek van der Kooy’s lab at the University of Toronto. See tweets live from #TMM2016 via @SamanthaZY here. Last week, 430 Canadian scientists, trainees, industry professionals, science communicators and international guests gathered in the picturesque ski town of Whistler, British Columbia for the annual Till & McCulloch meeting (TMM). …

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ISSCR Releases Flood of Stem Cell Policy Docs

May 13, 2016 December 22, 2023 / By Professor Paul Knoepfler, Ph.D. / 4 Comments

A committee of the International Society for Stem Cell Research (ISSCR) did one heck of a document dump yesterday on stem cell policy, releasing a whole bunch of policy recommendations on stem cells and more. The torrent from ISSCR included a 37-page policy statement itself as well as several papers in top journals including the …

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Finally, Vacanti’s side of STAP cell implosion

February 22, 2016 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 11 Comments

A great new piece in The New Yorker by Dana Goodyear, The Stress Test, gives us a window into Charles Vacanti’s side of the STAP cell mess and includes recent quotes from him. It’s a long, fascinating look inside of STAP, the tangled and ultimately tragic scientific implosion that created and then brought down two Nature …

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Obokata questioned by police over STAP cell fiasco

February 18, 2016 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 1 Comment

Haruko Obokata was reportedly questioned by police in Japan today. The questioning relates to the STAP cell scandal that led to the retraction of two Nature papers. As first author of the papers, Obokata and other authors had reported that they could make IPSC-like cells simply via acid or other stress treatment. However, it is …

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Haruko Obokata (小保方晴子) new book on STAP cells & more

January 27, 2016 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 8 Comments

Haruko Obokata reportedtly has written a book that is somewhat of a memoir of her life including the STAP cell scandal. The exact nature of the book remains mostly a mystery at this point. It should be out on the 2nd anniversary of the STAP cell papers being published. Kyodo News gives some more details …

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Waseda reportedly will revoke Haruko Obokata (小保方晴子) doctorate

October 30, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 3 Comments

Media in Japan are reporting that Waseda University will shortly revoke the Ph.D. of STAP cell scientist Haruko Obokata (小保方晴子). A hat tip to blog reader Tom on this story. The thesis contained plagiarized material and problematic data as did the Nature papers on which she was first author. Those papers were retracted and …

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New Nature papers debunk STAP cells

September 23, 2015 January 12, 2024 / By Professor Paul Knoepfler, Ph.D. / 6 Comments

Today marks nearing the completion of a full circle for one of science’s biggest controversies: the STAP cell fiasco. Today STAP cells are completely refuted with the publication of two new papers in Nature and we know much more–with some notable gaps still–about what went wrong. STAP cells debunked In January of last year, an …

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Did NHK Violate Rights of Obokata (小保方晴子) on STAP?

August 25, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 13 Comments

The Japanese public broadcasting system, NHK, has been accused by scientist Haruko Obokata of violating her human rights. Obokata was the primary researcher involved in the STAP cell fiasco in which two ultimately retracted Nature papers contained duplicated, plagiarized, and manipulated data. She was certainly not the only researcher on those papers, but overall she …

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