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Nobel Prize 2012 for stem cells to Yamanaka & Gurdon: why only 2?

Nobel-Prize

Stem cell revolutionaries Drs. Shinya Yamanaka and John Gurdon have won the 2012 Nobel Prize for Physiology or Medicine. Gurdon cloned for the first animal, a frog, and Yamanaka produced induced pluripotent stem cells (iPSCs), a kind of stem cell with the power of pluripotency, but derived from ordinary non-stem cells. Gurdon’s work was based […]

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iPS cells are similar to cancer cells paper, part 2: unsettled reviewers

I’m a fan of iPS cells, but my lab has been concerned about the similarities between induced pluripotency and cancer formation for many years. We just now published a paper that directly addressed the similarities of cancer and iPS cell transcriptomes. These are cause for concern and need to be faced as we contemplate clinical

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iPS cells are similar to cancer cells: part 1 of discussion of new paper

My lab just published a somewhat provocative paper (still in unproofed form at this point) arguing that iPS cells are very similar in some ways to cancer cells. How did we get to that conclusion (discussed in this post today, part 1 of the story) and what’s the back story on this paper (discussed in a later

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Great big picture talk on cancer by Edison Liu at UC Davis Cancer Center Symposium: cool ‘long tail’ concept

Yesterday I managed to get to see a fabulous talk by Dr. Edison Liu, President and CEO of The Jackson Laboratory in Maine. I was able to squeeze it in, in between working on my R01 proposal and preparing for teaching histo to the med students here at UC Davis Med School. Dr. Liu was

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Stem cells for COPD including emphysema: are we there yet?

Chronic obstructive pulmonary disease (COPD) is a relatively common, often debilitating illness, which has a major impact on the people of the world. In the U.S. alone, COPD costs the country almost $50 billion a year not to  mention untold suffering. Most of us know someone who has COPD. COPD is an umbrella term that

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Handy BioMed Science Tools

Chromatin/Genomics/Transcription Tools ChIP grade antibodies MOTIF enrichment tools for DNA analysis GREAT (Stanford) CEAS HOMER MEME ENCODE Promoter Array On-line Analysis Online Tiling Array Analysis ChIP-Seq data on-line Analysis Plant Tools Transfac UC Davis Genome Center Methylation tools Yeast tools Fly ChIP-chip database   General Science Tools Blast Search Genomic Blast Search ENSEMBL Blat Search

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