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Monkeying around with myostatin: on the road to healthier humans or human hulks?

October 25, 2015 February 11, 2024 / By Professor Paul Knoepfler, Ph.D. / 6 Comments

The myostatin gene has been getting quite a bit of attention lately. The buzz surrounds the idea of inhibiting myostatin either through gene therapy or via germline human genetic modification. In this way, some hope to create people with more muscle. Myostatin, which also goes by the acronym MSTN, has an inhibitory function on muscle. …

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GMO Sapiens book teaser: time to talk frankly on human genetic modification

October 23, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 2 Comments

I’ve written a new book on human genetic modification. This is my second book as the first one was Stem Cells: An Insider’s Guide, which is currently the top stem cell book on Amazon. The new book is called GMO Sapiens: The Life-Changing Science of Designer Babies. You can pre-order it here at Amazon or over here at my publisher’s …

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Noah’s GMO ark: is it ethical to create GM or cloned animals for sale as pets?

October 21, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 8 Comments

CRISPR-ful Noah’s Ark? Even as much of the discussion surrounding powerful new gene editing and cloning technologies has centered on their possible use in humans, the creation of genetically modified (GM) and cloned animals has advanced at warp speed. Some of these efforts have been for research, which is justified. But many seem profit-centered and …

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Tick Tock Genetic Clock: How soon until first DIY CRISPR of self?

October 15, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 5 Comments

I just did a blog post today on the striking story of someone doing DIY CRISPR gene therapy on themselves. A question came to mind. How long until someone does a DIY attempt to CRISPR themselves? In the DIY gene therapy story, the person was injected with so-called “gain-of-function” viruses to try to reap health …

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Nature mixed signals on 3-person IVF: deep risks, but forge ahead

October 11, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 2 Comments

Nature recently published a thorough, insightful piece on the major risks that would come with the use of so-called 3-person IVF (aka mitochondrial transfer or 3-parent baby method). In the UK 3-person IVF has, as of earlier this year, the government’s blessing to proceed despite the many serious unresolved risks that Nature‘s own piece so nicely …

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TGIF links to tip-top weekend science reading

October 9, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D.

Some TGIF stuff to read, think about, and do. Still a few days left to nominate your favorite candidate for my Stem Cell Person of the Year Award for 2015. Who had the most impact this year? Thought outside the box? Let me know. Lots of great nominees already. If you haven’t already, check out …

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List of Speakers for NAS Meeting on Human Gene Editing

October 1, 2015 March 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 4 Comments

Who will be speaking at the upcoming National Academy of Sciences (NAS) meeting on human gene editing? So far we haven’t known, but now we do (if you are eager to find out, skip to bottom of the post). The organizers of the meeting can be found here. Keep in mind that it is probable that …

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Weekend science reading: fantastic found links including on CIRM

September 26, 2015 March 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 4 Comments

David Jensen reports on the future of CIRM as a “beautiful machine”. CIRM funds brain cancer research in a big way: Funding a clinical trial for deadly cancer is a no brainer. Glioblastoma is a fatal tumor that needs new clinical approaches so this is exciting. One of the goals of my lab is to find new …

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Poll: Is sex a form of human genetic modification?

September 22, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 2 Comments

Is sex a form of genetic modification? A fairly common argument out there is that human decisions about mates and then their actual sexual reproduction are forms of human genetic modification. Sex is also sometimes equated with genetic modification of organisms by a few scientists. What do you think? Are these things equivalent? Similar? Not …

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