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Mitochondrial Replacement Hype Goes Nuclear Including by Wellcome Trust

June 9, 2016 / Professor Paul Knoepfler, Ph.D. / 4 Comments

A new paper from a UK team yesterday showed that mitochondrial replacement therapy faces a serious and difficult safety hurdle fitting with similar findings from an earlier recent study from a different team led by Dieter Egli, but the UK media and some scientists there are engaging in hype, claiming the exact opposite. They are pushing the unscientific […]

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TGIF Science: funding, CRISPR v. NgAgo, secrets, Zika, & more

May 20, 2016 / Professor Paul Knoepfler, Ph.D. / 2 Comments

Some stuff on my mind for our TGIF Science this week. Research Funding Ups: NIH. Is it my imagination or is NIH funding slightly improving? This is the overall vibe I’m hearing from the trenches. Research Funding Ups and Downs: CIRM. CIRM funded some basic research to the tune of a total of $4 million,

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UK should freeze mitochondrial replacement as Egli paper ID’s serious problem

May 19, 2016 / Professor Paul Knoepfler, Ph.D. / 1 Comment

An important new Cell Stem Cell paper from Dieter Egli’s lab points to an inherent, serious problem with so-called 3-person IVF or mitochondrial replacement technology that warrants putting an immediate hold on all efforts to use it in humans. I have pasted the graphical abstract from the paper below. For years a few of us scientists and

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In Depth Report from April 29th Paris Human Gene Editing Meeting

May 11, 2016 / Professor Paul Knoepfler, Ph.D.

Editor’s note. Caroline Simons attended both the April 28th (see her report on that here) and 29th Paris meetings on human gene editing/genetic modification. Today, we have her in depth report on the April 29th meeting. I have posted her piece in full with only minor edits. If you are in a rush you can

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Paris human gene editing workshop summary

April 29, 2016 / Professor Paul Knoepfler, Ph.D.

Editors note: This is a guest post from Caroline Simons who is attending the two Paris meetings on human gene editing. For more background on those meetings see here. By Caroline Simons There were just over a hundred participants at the workshop organized by the Federation of European Academies of Medicine, the UK Academy of

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George Church chat: CRISPR people, Zika, weapons

April 18, 2016 / Professor Paul Knoepfler, Ph.D. / 4 Comments

I talked last year about human genetic modification by CRISPR with George Church a year ago. Now we’ve followed up with a long chat on this topic going into much more detail and with questions on recent developments. Each question is listed numerically and then there is a back and forth on that question with George

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A role for nationalism in science?

April 17, 2016 / Professor Paul Knoepfler, Ph.D.

One of the rewarding things about being a scientist is the opportunity to connect and even collaborate with other scientists around the world., but at the same time there is nationalism in science too. Some nations, perhaps most of them, and some scientists feel a sense of competition against others at least some of the time.

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CRISPR embryo OK signals ongoing liberal UK trend on human modification

February 1, 2016 / Professor Paul Knoepfler, Ph.D. / 5 Comments

With the approval today of the use of CRISPR in human embryos, the UK continues its recent trend toward a more permissive regulatory policy on human genetic modification. There are both risks and scientific benefits that come along with this trend. Last year the UK approved an experimental technology with the goal of preventing the

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List of 20 stem cell predictions for 2016

January 4, 2016 / Professor Paul Knoepfler, Ph.D. / 1 Comment

What will the new year have in store for stem cells? 2016 promises to have many striking stem cell developments. Below are my top 20 stem cell predictions for what is to come this year in no particular order. Share your stem cell tea leaves in the comments please. Another stem cell biotech acquisition by pharma

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Highlights from day 2 of #GeneEditSummit

December 3, 2015 / Professor Paul Knoepfler, Ph.D.

Day 2 of the Human Gene Editing Summit in DC (#GeneEditSummit) was quite interesting and added more depth to the meeting overall. For specific talks, see my two posts from yesterday here and here. Also see my top takeaways from Day 1. What were the top highlights of Day 2 of #GeneEditSummit? Somatic work. We

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