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Live Blogging #GeneEditSummit Day 1 Post #3: human germline modification

December 1, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 2 Comments

Robin-Lovell-Badge-Peter-Braude-George-Church

The post-lunch session is “Applications of Gene Editing Technology: Human Germline Modification”. Prior to hearing it I’m curious how cautious or gung-ho the speakers will be, or if their gestalt will be one of balance in the middle somewhere. Robin Lovell-Badge, The Francis Crick Institute, was the moderator of this session. He said, “We’d be …

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FDA approves 1st GM animal (fast-growing salmon) to eat

November 19, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 14 Comments

After a seemingly endless period of review, the FDA has approved the genetically modified (GM) AquaBounty salmon for sale and consumption. Update: You might find my interview with George Church on CRISPR and gene modification interesting. I don’t see any particular reason to think that this GM fish as a food would pose any significant …

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Claim of Liz Parrish DIY gene therapy linked to unlicensed stem cell clinic

October 15, 2015 November 11, 2021 / By Professor Paul Knoepfler, Ph.D. / 20 Comments

In a strange, but fascinating tale recounted by Antonio Regalado in an article over at MIT Tech Review, we hear the first claim of a do-it-yourself (DIY) gene therapy. The owner of a small biotech called BioViva, Liz Parrish, reportedly traveled from her home in Seattle to get an unapproved, experimental gene therapy in another …

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List of Speakers for NAS Meeting on Human Gene Editing

October 1, 2015 March 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 4 Comments

Who will be speaking at the upcoming National Academy of Sciences (NAS) meeting on human gene editing? So far we haven’t known, but now we do (if you are eager to find out, skip to bottom of the post). The organizers of the meeting can be found here. Keep in mind that it is probable that …

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TGIF: NatGeo sell out, GM Humans, Wild West, Science backstabbing, & more

September 11, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 3 Comments

It’s a shame that National Geographic (NatGeo) has become part of a corporate empire that is not always consistent, to put it nicely, with data-based reality. Can NatGeo maintain its credibility and impact, when it is owned by a climate change denier (quoted for example as dissing folks as “extreme greenies”) who also has other …

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Recommended thought-provoking books…and one I’ve been writing

September 3, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D.

In choices of fictional books to read I gravitate toward sci-fi and fantasy. For example, in late 2014 and through the first few months of this year I read all the Game of Thrones books. The first three of those were the best and I thought definitely better than the TV show, although it’s pretty good …

Why I Disagree with Steven Pinker On CRISPR

August 17, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 12 Comments

Professor Steven Pinker of Harvard has been making the case recently that when it comes to novel biotechnologies such as CRISPR-Cas9 that bioethics should just get out of the way. Further, he has argued that we do not need a moratorium on clinical use of CRISPR-Cas9 for human genetic modification. In fact, he says that …

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Conversation with Harmit Malik on Gene Drive & Genetics

August 16, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D.

Gene drive is a powerful, emerging genetic technology that can force genetic modification into an entire population. For more background on gene drive you can read my previous post. It’s a very exciting, but potentially dangerous technology with sizable possible risks. Recently I had an intriguing conversation with leading geneticist Harmit Malik on gene drive. What …

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Why interview Steven Pinker on my blog if I strongly disagree with him?

August 13, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 2 Comments

Earlier this week I posted an interview with Steven Pinker on CRISPR, human germline modification, and bioethics. With only a few exceptions, I strongly disagree with Pinker’s philosophy in these areas and I knew going into the interview that his answers would likely go against my own views. I also expected the interview would anger …

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Exciting CRISPR-powered “gene drive” also has scientists deeply concerned

August 12, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D.

Scientists studying genetics are both excited and worried about a powerful, new technology called “gene drive“. Some have been raising serious concerns about gene drive and in certain cases calling for proactive regulation, which is unusual in science. This method is so powerful because it is designed to induce genetic changes in an entire population …

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