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Why Mitalipov’s ‘magic’ room for human embryo CRISPR may give us pause

October 3, 2017 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 7 Comments

The debate over whether the main conclusions of the Nature paper on human embryo CRISPR led by Shoukhrat Mitalipov’s lab at Oregon Health Sciences University (OHSU) are correct remains unresolved. Note that Nature just added an editorial alert just above the references section to their paper: “Updated online 02 October 2017. Editorial Note: Readers are alerted that some …

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Mulling over that Mitalipov human embryo CRISPR pub, still many questions

September 12, 2017 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 6 Comments

What really happened at the DNA level in the experiments in that high-profile CRISPR of human embryos paper from a team led by Shoukhrat Mitalipov at OHSU? Is the team right that they successfully conducted CRISPR of human embryos to correct a mutant gene, as they reported in their Ma, et al. Nature paper? Or is the Egli, …

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4 key reasons Mitalipov paper doesn’t herald safe CRISPR human genetic modification

August 7, 2017 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 2 Comments

We can be confident that human genetic modification via CRISPR’ing of embryos soon will be safe and effective after that new exciting Mitalipov team paper, right? Wrong. The reality is far more complicated and interesting on the tech side. In a nutshell, I see the paper as a significant scientific, but not necessarily medical advance. …

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Review of Mitalipov paper CRISPR’ing human embryos: transformative work on the edge

August 2, 2017 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 3 Comments

In the same way perhaps that some excited relatives or parents-to-be both gush and worry about a baby before it is even born, our field has been transfixed for a week by the Mitalipov paper on CRISPR’ing human embryos even though the paper just now came out. Now that the paper is out, we can …

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Big 5 questions anticipating Mitalipov human embryo CRISPR paper

July 31, 2017 February 1, 2021 / By Professor Paul Knoepfler, Ph.D.

The human embryo CRISPR paper with Shoukhrat Mitalipov as senior author is coming soon. It will reportedly be focused on the use of CRISPR to genetically modify viable human embryos for reversal of a disease-associated mutation. While strangely press already broke early on this paper last week, as much as a week before the paper …

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CRISPR, human genetic modification, & a needed course correction

June 26, 2017 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 9 Comments

Are designer babies made using CRISPR or other genetic modification technologies closer to reality today? If so, what exactly should we do about it? Researchers can use CRISPR to genetically modify just about any organism or its cells, but targeting humans is the subject of the most intense discussion including using CRISPR in the human germline …

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Human embryo CRISPR pub includes plagiarism: the victim’s unique account

May 18, 2017 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 5 Comments

Cut, modify, paste… It’s kind of a CRISPR mantra for those of us using gene editing in the lab. But it’s supposed to be happening just on DNA, right? Now it appears that someone on a team of human embryo CRISPR researchers possibly got carried away with the cutting-modifying-pasting mindset to take it beyond DNA to also do …

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Paper on 1st use of CRISPR in normal human embryos: problems remain

March 9, 2017 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 1 Comment

The first report of the use of CRISPR gene editing in normal human embryos was published today as a short paper from a team in China. There have been rumors for over a year that more CRISPR human embryo papers were coming including some using normal embryos. Here’s one and we can now expect more even …

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National Academies panel leaves door a crack open to future human genetic modification

February 14, 2017 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 6 Comments

A National Academies panel on human genome editing chaired by Alta Charo and Richard Hynes released its report today. While it covered both somatic and germline (heritable) human genetic modification, the latter topic is far more contentious. You can see the National Academies summary of their report here. You can read the full report here. …

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Interview with Fredrik Lanner who is CRISPR’ing healthy human embryos

September 26, 2016 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 2 Comments

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In the past year there has been a great deal of attention given to the potential use of CRISPR-Cas9 for gene editing in human embryos. An important recent development, described in a new NPR article by Rob Stein, is the use of CRISPR-Cas9 in healthy human embryos for developmental biology research by assistant professor Fredrik …

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