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Masayo Takahashi (高橋政代): exciting vision work advancing including with photoreceptors

December 22, 2019 December 22, 2023 / By Professor Paul Knoepfler, Ph.D. / 3 Comments

Masayo Takahashi is a leading stem cell researcher doing translational and clinical research on vision. She’s doing pioneering work on using pluripotent stem cells as a basis for helping patients with vision loss such as due to macular degeneration. She won The Niche’s Stem Cell Person of the Year Award in 2014 and a number …

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1st autologous IPS cell clinical trial for vision loss in the US

December 18, 2019 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 11 Comments

The NIH announced the launch of the 1st autologous induced pluripotent stem (IPS) cell trial for vision loss in the U.S., focused on macular degeneration. The protocol is based on a solid foundation of pre-clinical animal studies: “Researchers at the National Eye Institute (NEI) are launching a clinical trial to test the safety of a …

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Monkey-pig chimeras pub discouraging for similar human research toward organ transplants

December 12, 2019 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / Leave a Comment

pig-monkey-chimera-that-was-born-but-died

Michael Le Page over at The New Scientist reports on a new paper describing the birth of monkey-piglet chimeras. Unlike most such primate embryo chimeras formed in research in the past, these were allowed to be born. A litter of ten from the new monkey-pig research, two of which were chimeras, all rather quickly died …

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Whatever happened to the STAP cell scientists including Haruko Obokata?

November 14, 2019 January 12, 2024 / By Professor Paul Knoepfler, Ph.D. / 3 Comments

Once upon a time this blog and major outlets around the world were regularly writing about a Japanese stem cell researcher named Haruko Obokata (小保方晴子). Whatever happened to Obokata and the other folks directly involved in STAP cell research? First, a bit of background because maybe still a few people never heard of STAP cells …

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ViaCyte Q&A: CRISPR Tx quick progress, ongoing diabetes trial, & more

September 25, 2019 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 9 Comments

ViaCyte is one of the most exciting stem cell and regenerative medicine biotech companies so I like to try to check in with them regularly. Today’s post is my new interview with ViaCyte leader Paul Laikind on recent developments. We had a great chat about the science and how things are looking upbeat for the …

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Jeanne Loring: hES cell research, Bush, & her career

August 9, 2019 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 33 Comments

By Jeanne Loring A stem cell anniversary: 18 years ago today that the US initiated funding of human embryonic stem cell research. August 9, 2001 was a big day for me. George W. Bush was the US president, and it was an understatement to say that I was not very fond of his policies; but …

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Don’t mess with (mother) Nature: why risk taking on a powerhouse journal?

February 28, 2019 June 6, 2022 / By Professor Paul Knoepfler, Ph.D. / 2 Comments

When I was a kid there was this commercial on TV for Chiffon margarine (fake butter) with the slogan, “It’s not nice to fool mother nature!” As a kid I thought it was dumb but kind of funny. A modified version of that mother nature advertising slogan has become a cultural tagline. Don’t mess with …

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Hope on Parkinson’s front: Japan IPSC trial 1st patient

November 18, 2018 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 2 Comments

Fig-3i-Kikuchi-et-al.-Nature-2017-IPS-cell-Parkinsons-

In Parkinson’s Disease patients develop neurological dysfunction as they lose a special kind of brain cell called dopaminergic (or dopamine) neurons. While a number of different approaches to this disease have been studied for decades, nothing has proven particularly successful in slowing its progression. As a result there has been a big need for novel thinking …

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Digesting new esophageal organoids papers

September 25, 2018 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 1 Comment

There’s a new paper in Cell Stem Cell on esophageal organoids that has really caught people’s attention. It is entitled, “3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling.” It comes from a team led by Jianwen Que. Update: I didn’t realize when I first did this post that …

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Mulling over latest CRISPR tumult, this one from Nat Biot pub on DNA lesions

July 17, 2018 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 4 Comments

If it seems to you like dramatic cautionary tales about CRISPR accompanied by all sorts of media are coming at us more frequently, it’s not your imagination. In the latest yesterday, it was reported in a new paper led by Allan Bradley that CRISPR-Cas9 results in sometimes large-scale chromosomal lesions at or even away from the …

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