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Weekly reads: reprogramming hearing loss, heart disease, eye drops, sickle cell

April 30, 2023 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

It’s mostly been a week of good and encouraging news in the regenerative medicine space including with gene therapies maybe with the exception of some eye drops warning (more below). There’s realistic hope for an approved sickle cell disease soon. I also see some long-term positive news on hearing loss research. Hematopoietic stem cell transplant […]

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Questions on National Academies in vitro gametogenesis (IVG) meeting sponsorship

April 26, 2023 / Professor Paul Knoepfler, Ph.D. / 2 Comments

Research on in vitro gametogenesis or IVG is jumping ahead and such work could one day lead to new infertility treatments. In vitro gametogenesis is the process of producing gametes (sperm and eggs) from stem cells. Those powerful stem cells, called iPS cells, can be made from ordinary adult cells like skin or blood cells.

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Weekly reads: genome sequencing, chemical reprogramming 2.0

April 2, 2023 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

I wrote earlier this week about genome sequencing of famous dead celebrities, pointing out that the trend seems full of ethical complexities. Genome news More broadly, sequencing the genomes of non-celebrities from hundreds or thousands of years ago can be important research. A new NYT piece covers such work on the Swahili people. Such research

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Are immortal jellyfish actually mortal?

January 24, 2023 / Professor Paul Knoepfler, Ph.D. / 1 Comment

About ten years ago I ran across the organism called the immortal jellyfish. Luckily I didn’t get stung because it wasn’t an in-person encounter like while swimming. Rather, I came upon the idea that these guys lived forever. Someone was even selling an immortal jellyfish extract. They claimed it would reverse aging in people. That

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3rd Invitrx warning highlights FDA oversight weakness

January 4, 2023 / Professor Paul Knoepfler, Ph.D. / 8 Comments

The FDA seems oddly slow in oversight of unproven stem cell clinic-related firms like one here in California called Invitrx Therapeutics. I’ve written before about Invitrx, but interactions between them and the FDA have continued including a new warning letter. It’s become a puzzling situation. More broadly, the FDA has done relatively little in the past

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Weekly reads: KRAS G12C, eLife journal controversy, bird iPSCs

October 30, 2022 / Professor Paul Knoepfler, Ph.D. / 2 Comments

If you’ve never heard of the KRAS G12C mutation, it’s a particularly frightening mutation present in numerous cancers. Like the MYC oncogene, many people view mutations in RAS as undruggable, but new efforts show some glimmers of hope. The drug Sotorasib has been approved by the FDA to target the KRAS G12C mutation. Here’s a

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Review of cord banker Viacord: dubious autism claims & other concerns

September 6, 2022 / Professor Paul Knoepfler, Ph.D. / 2 Comments

Viacord is one of the most well known firms in the for-profit cord blood banking industry. Today’s post is a review of the firm. I see concrete reasons for concern. What is Viacord? | Dubious autism claims | Viacord cost | Overall Review | References What is Viacord? As a cord blood banking firm, Viacord freezes

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Weekly reads: taste buds, organoids, good news on CRISPR safety

August 28, 2022 / Professor Paul Knoepfler, Ph.D. / Leave a Comment

As I’ve mentioned recently, it’s my busy time for medical school teaching and not long ago we did a GI lab that included one of my favorite structures in the course: taste buds. Taste buds The medical students seem fascinated with taste buds too. I can tell as their professor when something is particularly interesting

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Weekly reads: teratoma in iPSC trial, Piero Anversa & friends, Athersys, China Initiative

June 26, 2022 / Professor Paul Knoepfler, Ph.D. / 1 Comment

It’s been mostly a downbeat week on the stem cell news front including a deep revisit by Reuters to the Piero Anversa case that has new revelations. It’s ugly stuff involving other folks too. We’ll start on the iPS cell front, where a trial participant had a teratoma. I’ve had a long-standing interest in the

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