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Why Mitalipov’s ‘magic’ room for human embryo CRISPR may give us pause

October 3, 2017 / Professor Paul Knoepfler, Ph.D. / 7 Comments

The debate over whether the main conclusions of the Nature paper on human embryo CRISPR led by Shoukhrat Mitalipov’s lab at Oregon Health Sciences University (OHSU) are correct remains unresolved. Note that Nature just added an editorial alert just above the references section to their paper: “Updated online 02 October 2017. Editorial Note: Readers are alerted that some […]

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New FDA Inspection 483s: Insights on Stem Cell Clinic & Cell Surgical Network

September 28, 2017 / Professor Paul Knoepfler, Ph.D. / 5 Comments

Two new FDA inspection reports called 483s provide fresh insights on a stem cell clinic, the network of clinics that it belongs to, and adverse events in patients. These reports detail issues the FDA found at the stem cell clinic California Stem Cell Treatment Center and its parent chain of clinics, Cell Surgical Network. The

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Dissecting the FDA’s big, fat stem cell dilemma

September 26, 2017 / Professor Paul Knoepfler, Ph.D. / 18 Comments

Right now the FDA has a big fat stem cell conundrum on its hands. The agency is faced with a tough dilemma as how to deal with fat (adipose) stem cell products and the large number of businesses who sell them. Are fat/adipose stem cells a drug or not? If yes, what does the FDA do

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Ask Me Anything (AMA)

September 21, 2017 / Professor Paul Knoepfler, Ph.D.

Inspired by the Reddit AMAs (Ask Me Anything) that I’ve done over the past few years, I’m launching this new page (new as of September 2017) where I invited readers of this blog to ask me questions. The questions can be about stem cells, CRISPR, brain cancer research, other science topics, about my lab’s research,

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Cool stem cell papers: antibody reprogramming, organoids, gravity, & more

September 13, 2017 / Professor Paul Knoepfler, Ph.D.

The past few weeks have brought some exciting, thought-provoking stem cell papers and developments in the regenerative medicine field. Here’s a list of stem cell papers in the media that struck me as particularly cool along with some other developments in the field. Human Stem Cells Fight Parkinson’s Disease in Monkeys Organoids Reveal Clues to Gut-Brain

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CRISPRcon guest post: Hope for a brighter future

August 19, 2017 / Professor Paul Knoepfler, Ph.D.

By Anna Everette “In our society, we have an addiction to vertical genetic transmission. It’s called sex and having a child who looks like you”. This was perhaps the most memorable quote from the event’s keynote speaker, Greg Simon, Director of the Biden Cancer Initiative. It also happens to highlight the most compelling reason to

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3 Ways Stem Cells Theoretically May Help John McCain Beat Brain Tumor

July 23, 2017 / Professor Paul Knoepfler, Ph.D. / 2 Comments

I was really sad when I heard about John McCain’s diagnosis with a glioblastoma, a particularly nasty type of brain tumor that we study in my lab when it shows up in children. My own battle with prostate cancer starting almost 8 years ago might have sensitized me to this news even though I’m in

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Cynata stem cell trial update: CEO Ross Macdonald interview

July 3, 2017 / Professor Paul Knoepfler, Ph.D. / 2 Comments

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Stem cell clinical trials have a certain gravitational pull for me as I’m always fascinated by them and since the new Cynata trial is moving forward, I recently did an interview their CEO, Dr. Ross A. Macdonald to find out more. PK: Cynata’s recently initiated clinical trial aims to treat GVHD as have other stem

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Hans Keirstead interview on his congressional run, how you can help

June 30, 2017 / Professor Paul Knoepfler, Ph.D. / 3 Comments

Hans Keirstead is one of the top stem cell scientists in the world who has been doing cutting edge research including on using stem cells to reverse paralysis where he teamed up with super patient advocate Roman Reed (see the two pictured at right), but now he is also running for Congress. How cool is that?

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Highlights of ISSCR2017 – A Biomedical Engineer’s Perspective

June 25, 2017 / Professor Paul Knoepfler, Ph.D.

ISSCR meeting review By Agnes Soos Amid the hustle and bustle of downtown Boston, nearly four thousand researchers and exhibitors gathered for the 15th Annual ISSCR Meeting. With presentations from over thirty plenary lectures, and dozens of others featured in concurrent sessions and the daily Innovation Showcases, there definitely was no shortage of exciting research

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