I tend to perhaps over-focus on human CRISPR or gene editing, but other applications including in agriculture are definitely going to be huge. CRISPR in agriculture One that I’ve been following for a long time is the use of CRISPR to prevent cows from growing horns. Why is that a big deal? Just in the […]
Weekly reads: CRISPR chicks, HSCs, sequencing Mendel Read More »
Out of the blue this past week we lost Kevin McCormack of CIRM to a heart attack. When I first heard, my reaction was that can’t be, but it is. About Kevin McCormack If you aren’t familiar with him, Kevin was officially Director of Patient Advocacy at our state’s Stem Cell Agency. However, he was
Weekly reads: Kevin McCormack passes, HSCs & RXR, Ethics Read More »
Something called a P shot has sparked interest from some men interested in high-risk attempts at enhancement. The goal of today’s review post is to fact-check P shots. They’re sold for supposed penis enhancement or to address erectile dysfunction (ED). I’ll also fact-check so-called O shot stabs at vaginal rejuvenation or enhancement. These are both
Reviews of P shot & O shot stabs at sexual enhancement Read More »
Histone proteins such as histone H3 are often popping up in science writing and news sometimes includes specific modified forms of H3 including one that we scientists call H3K27me3. What is in this article What is H3K27me3? | The histone code | H3K27ac and H3K27me3 function | H3K27 and human disease | References The goal of today’s post
Histone code series: H3K27me3 & H3K27ac functions & roles in diseases like DIPG Read More »
Eight years ago two new Nature papers broke on the scene reporting supposed STAP cells with one of the senior authors, Charles Vacanti of Harvard, most well known previously for making the so-called “Vacanti mouse” along with his brother Joseph. The Vacanti mouse had a bioengineered human ear growing on its back. While STAP cells
Recommended reads: Dux, 3D printed ear brings Vacanti mouse to mind, AMD, more Read More »
There’s nothing quite like getting a new paper out as a scientist running a research lab so this week we can celebrate our new pediatric brain tumor study. I’ll start the weekly reads with that paper. Of course, getting new grants is amazing too but there’s more of a feel of completion after a paper
Weekly reads: our new brain tumor paper, levitation, dear doctor, Japan, more Read More »
This has been one of those weeks where I spent some time thinking about taking risks in science. How much risk one should take? Risks can come in many forms. It could be at the core level at the bench doing specific experiments and not others. There’s risk in clinical trials, and even in advocacy. Sometimes
Weekly science reads: Macchiarini trial, somites, CRISPR babies Read More »
We often don’t think of them that way but reproductive cells like sperm and egg are also relatives of stem cells, and it turns out that there are stem cells that make the reproductive cells too like sperm stem cells. Sperm and germ cell stem cells DNMT3A-dependent DNA methylation is required for spermatogonial stem cells
Recommend reads: CRISPR baby guy free, DNMT3, sperm, Editas, hearing loss, reprogramming Read More »
David Weinberg over at Science-Based Medicine has his part two of a deep dive into the so-called SCOTS trial, which is a non-traditional pay-for-play study. I highly recommend it. SCOTS trial under the magnifying glass In this piece, Weinberg provides interesting background on the two people running SCOTS. I’ve had many concerns about the SCOTS
Recommended reads: engineered niche, ALS, SCOTS trial, human genome “done” Read More »
Stem cell research relies on some unusual reagents at times including a cell culture product called Matrigel. One of the challenges with such reagents is that if they suddenly are back-ordered it could bring some research to a halt. Matrigel has been in short supply for the last year or so. These products also tend
What is Matrigel, why a shortage, & alternatives? Read More »