In a major first for the stem cell and regenerative medicine fields, a patient in Japan today received a pioneering transplant of a retinal pigmented epithelial (RPE) sheet made from induced pluripotent stem (iPS) cells, also known by the acronym IPSC. This is the first ever iPS cell-based transplant into a human. The patient is […]
Landmark: patient receives first ever iPS cell based transplant Read More »
A new patent dispute has exploded in the stem cell field related to induced pluripotent stem (iPS) cells. What’s going on? In 2006, Shinya Yamanaka reported cellular reprogramming to create mouse induced pluripotent stem (iPS) cells in Cell and the next year multiple groups along with Yamanaka’s reported creating human iPS cells. It’s no exaggeration
Challenge tries to cancel Yamanaka iPS cell patent Read More »
Just how good are human embryonic stem (ES) cells made by therapeutic cloning via nuclear transfer, with the successful technique first reported by the lab of Shoukhrat Mitalipov at OHSU last year? How do they compare to induced pluripotent stem (iPS) cells or traditional ES cells made from IVF embryos? A new paper in Nature directly tackles these
Review of Mitalipov Nature paper: cloned ES cells vs iPS cells Read More »
In the interview below I talk with Dr. Masayo Takahashi, who is leading a team conducting the first ever in-human clinical study based on iPS cells. The work began with patient enrollment on Aug. 1, 2013 in Japan. Masaya Takahashi background 1. Can you tell us a bit about your background? As an M.D./Ph.D. and
Masayo Takahashi Interview on iPS cells, clinical studies, & more Read More »
I recently did a poll asking readers of my blog to vote on the iPS cell paper of the year for 2013. The vote kind of seesawed at the beginning, but in the end with 100 votes cast the paper by the Hannah lab on near-perfect iPS cell production won out (see votes at left).
Hannah near-perfect reprogramming voted as iPS cell paper of 2013 Read More »
The stem cell field has seen quite a few high-profile, intriguing papers on induced pluripotent stem (iPS) cells. Which do you think is the iPS cell paper of the year for 2013? The iPS cell field continues to advance rapidly. If you think one not listed is the best, let us know in the comments.
iPS cell paper of the year 2013: cast your vote Read More »
A team led by Shinya Yamanaka has published a new study reporting analysis of defective induced pluripotent stem (iPS) cells in the journal PNAS. Part of what I liked so much about this paper is that it tackled a very real, but controversial area of stem cell research. By this I mean the reality that a
Review of New Yamanaka Paper on Defective iPS cells Read More »
What if you could reprogram cells inside of an organism to a different fate and, for instance, make IPS cells? We can, right? But when most of us think about making induced pluripotent stem (iPS) cells, we imagine it all happening in a little plastic dish in our labs or in our colleague’s labs, not
Stem cell journal club: dishing on Nature paper on making iPS cells inside mice Read More »
I recently did a poll on people’s reactions to the new paper reporting use an all-chemical approach to making iPS cells through cellular reprogramming. I got a good number of responses relatively quickly. The results so far suggest that by far most people think it is too soon to know the importance of this new
Stem cell field mostly taking a wait-and-see attitude toward all chemical iPS cells Read More »
In a rare sign of stem cell international regulatory unity, the Japanese Health Ministry (厚生労働省) and the US FDA have agreed to develop a joint, unified regulatory framework for clinical studies of human iPS cells for use in treating retinal diseases. Presumably the rules would also guide clinical use of iPS cells to treat other
FDA & Japanese Health Ministry (厚生労働省) To Develop iPS cell clinical rules Read More »