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Steven Pinker interview: case against bioethocrats & CRISPR germline ban

August 10, 2015 / Professor Paul Knoepfler, Ph.D. / 15 Comments

CRISPR-Cas9 gene editing technology is red-hot right now and I’ve been doing interviews with various thought leaders on it, which today includes Steven Pinker. This technology has great power for research in the lab and there are hypothetical transformative clinical applications of CRISPR too. The latter efforts could include experimental attempts at reversal of disease-causing […]

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Michael Cea ISSCR chat with Jeanne Loring on stem cell field

August 5, 2015 / Professor Paul Knoepfler, Ph.D. / 3 Comments

ISSCR Chat By Michael Cea Jeanne Loring of the Scripps Research Institute in La Jolla, California kindly sat down with me at the ISSCR annual meeting for a broad discussion of her history, views on the field and developments in the science. I found Jeanne a refreshing character, as I did a number of others I was

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Global transhumanism leader Natasha Vita-More on human germline modification

August 3, 2015 / Professor Paul Knoepfler, Ph.D. / 1 Comment

In my continuing series of conversations with thought leaders related to heritable human modification, today’s post is an interview with Natasha Vita-More, a pioneer in the transhumanism movement and Chairman of the Board of Directors of Humanity+ (H+), the global transhumanist organization. Where do you see transhumanism today? Has it changed over the years? What

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Historic turning point for IPS cell field in Japan?

August 2, 2015 / Professor Paul Knoepfler, Ph.D. / 24 Comments

As many of you know, the pioneering, first of its kind IPS cell clinical study in Japan has been suspended as I first blogged about here.2020 Update: I believe a version of this study is ongoing. In the comments section of that blog post there has been a helpful overall discussion that has involved Dr.

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Fantastic organoid voyage: views from inside organoids

July 30, 2015 / Professor Paul Knoepfler, Ph.D.

The classic sci-fi movie Fantastic Voyage keeps coming to mind for me as I see and do research involving organoids. In it, the heroes travel inside of the human body in a craft, observing all kinds of awesome biology in an up close and personal kind of way on route into the brain with the goal

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White House Gets Going on Genetics

July 11, 2015 / Professor Paul Knoepfler, Ph.D.

The White House seems to be getting more active on genetics in the last six months. It’s refreshing to see them actually talking about real, important science. My feeling has been that up until now they’ve been giving too little attention to science so even if you may disagree with some aspects of what they

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Stem Cell Meetings & Conferences 2016

July 7, 2015 / Professor Paul Knoepfler, Ph.D. / 24 Comments

Below is a list of upcoming stem cell and regenerative medicine conferences and meetings for 2016. If you do not see your meeting, please let me know and I will include it. This list is meant to be as inclusive as possible, but by listing specific events I am not necessarily endorsing them. January Molecular

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Carla Kim & Hans Clevers talks on organoids at #ISSCR2015

June 26, 2015 / Heather Main / 4 Comments

Organoids are pretty big in stem cells right now with the last couple of years having attracted a lot of media attention on mini lungs, mini brains, mini kidneys, mini guts and more, giving the impression that scientists know how to specify and organise cells into mini functional organs in the lab. Organoids have become

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CIRM 2.0 starts off with a bang

May 31, 2015 / Professor Paul Knoepfler, Ph.D.

CIRM has reinvented itself in a new form, CIRM 2.0, under the leadership of its new President Randy Mills. CIRM is almost like a stem cell that has changed into another new kind of stem cell. Us scientists could see the change coming in the “programming” at CIRM in terms of how it was operating as

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Guest Post by Chris Scott–The Great CRISPR Controversy: What’s Next?

May 20, 2015 / Chris Scott / 1 Comment

A decade ago I wrote an article in the journal Nature Biotechnology about the rise of a new gene editing technology called zinc finger nucleases (ZNF). It was one of those “drumbeat” discoveries: at the time, my sense was it would revolutionize how we deliver genes to cells and tissues, and profoundly change the way

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