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Unnatural Selection review: captivating mind-bender but needed more science

October 28, 2019 / Professor Paul Knoepfler, Ph.D. / 2 Comments

Unnatural-Selection-with-patient-Jackson-Kennedy

Today’s post is a review of Unnatural Selection, the new Netflix science docuseries focused on CRISPR and other disruptive genetic and reproductive technologies. The show is an interesting mix of personalities and stories from patients, scientists, biohackers, and more. One patient thread is the story of a wonderful little boy named Jackson Kennedy. He wants […]

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Grading my stem cell predictions for 2016: how’d I do?

December 26, 2016 / Professor Paul Knoepfler, Ph.D. / 1 Comment

Below are the 2016 stem cell predictions I made last year and their status now color-coded near year’s end. Green is right, orange is mixed bag, and red is flat out wrong. Overall, I did better than most past years with only having entirely blown it on four. Stay tuned later this week for my 2017 predictions,

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20 Nominees for Stem Cell Person of the Year 2016 Award

December 4, 2016 / Professor Paul Knoepfler, Ph.D. / 4 Comments

I received a score of great nominations for the Stem Cell Person of the Year 2016 Award and have briefly described the twenty nominees below. The point of the award is to honor the top positive stem cell leader who specifically thinks outside the box and takes risks. I’ve started an on-line vote where you can vote once per day for

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Yamanaka’s baby turns 10: ten IPS cell hot button bullet points

July 27, 2016 / Professor Paul Knoepfler, Ph.D.

Nobel Laureate Shinya Yamanaka, the first to produce induced pluripotent stem cells

Has it really been 10 years since induced pluripotent stem cells (aka IPS cells or IPSC) came onto the scene in the stem cell field? Yes, it was a decade ago that now Nobel Laureate Shinya Yamanaka (山中伸弥) published that seminal Cell paper on reprogramming to make mouse IPS cells and then human IPS cells

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Stem cell checkup: how are my 2016 predictions doing half way?

July 11, 2016 / Professor Paul Knoepfler, Ph.D. / 2 Comments

Each December I make stem cell predictions for the coming year and I did that for 2016 where I made 20 predictions. At around mid year I do a checkup on how my predictions are doing halfway and that is the purpose of this post. Below are my predictions that I made in 2015 for stem

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Paris human gene editing workshop summary

April 29, 2016 / Professor Paul Knoepfler, Ph.D.

Editors note: This is a guest post from Caroline Simons who is attending the two Paris meetings on human gene editing. For more background on those meetings see here. By Caroline Simons There were just over a hundred participants at the workshop organized by the Federation of European Academies of Medicine, the UK Academy of

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George Church chat: CRISPR people, Zika, weapons

April 18, 2016 / Professor Paul Knoepfler, Ph.D. / 4 Comments

I talked last year about human genetic modification by CRISPR with George Church a year ago. Now we’ve followed up with a long chat on this topic going into much more detail and with questions on recent developments. Each question is listed numerically and then there is a back and forth on that question with George

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New Mitalipov paper on stem cell mitochondria: challenge for IPS cell field?

April 15, 2016 / Professor Paul Knoepfler, Ph.D. / 11 Comments

A new paper from Shoukhrat Mitalipov’s lab on stem cell mitochondria points to a pattern whereby induced pluripotent stem (IPS) cells tend to have more problems if they are from older patients. New Mitalipov paper What does this paper mean for the stem cell field and could it impact more specifically the clinical applications of IPS

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Mini-bios on finalists for Stem Cell Person of the Year

November 8, 2015 / Heather Main

By Heather Main I was a little ashamed of myself that I didn’t know who half of the finalists were in Paul Knoepfler’s Stem Cell Person of the Year Award. I decided to look into it and find out what (or who) I have missed…..Interestingly, 3 of the 7 listed here are not scientists but

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Kelly Hills interview: human genetic modification & bioethics

August 20, 2015 / Professor Paul Knoepfler, Ph.D. / 5 Comments

Below is a conversation with bioethics commentator Kelly Hills (who BTW has a great blog), tackling some of the key issues surrounding the potential use of CRISPR-Cas9 technology to make heritable human genetic modification. I really appreciate her clear and insightful answers to some tough questions that many are grappling with today on this topic. Part

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