CIRM, the California stem cell agency, has funded hundreds of grants during its relatively short existence. You can do searches of these grants through a handy dandy web portal that CIRM has made available–it’s a very cool tool and I commend CIRM for making it available. I wish the tool had more options however including […]
Word Cloud of Every CIRM-funded grant yields some surprising insights Read More »
Periodically we do updates on the iPS cell field and now seems like a good time. Where do things stand? Here’s my top 5 list of action items for the iPS cell field in the coming year. 5.) Methods on the brain. A significant fraction, some would argue too high a fraction, of iPS cell papers
Top 5 iPS cell action items Read More »
Periodically we do updates on the iPS cell field and now seems like a good time. Where do things stand? Here’s my top 5 list of action items for the iPS cell field in the coming year. 5.) Methods on the brain. A significant fraction, some would argue too high a fraction, of iPS cell
Key iPS cell action items Read More »
Podcast for Week of July 5 Topics –Stem Cell Tourism in the U.S. –CIRM –Article in the Hill by stem cell opponent –Stem cell hype on aging Podcast for Week of July 11 Topics: –two papers on stem cell-based tissue engineering and one on stem cell treatments for heart disease, –the Republican candidates for
Yamanaka may have found a way to give exogenous Myc the boot from the iPS cell universe. It has always been a frustration in the iPS cell field that Myc, a proto-oncogene, is so important for reprogramming. Yes, you can make iPS cells (especially mouse) without Myc, but it can be orders of magnitude harder,
New iPS cell method: drop Myc or not yet? Read More »
Note that this post ¿Qué son las células madre? is one of our “Stem Cells Not Lost in Translation” series. You can see the full 2020 series of our stem cell white paper in 34 languages here. ¿Qué son las células madre? El cuerpo humano contiene cientos de diferentes tipos de células que son importantes
¿Qué son las células madre? Read More »
Sheng Ding’s lab reports today in Cell Stem Cell (you can read it here) that they have replaced all genetic factors in a new iPS cell reprogramming method except Oct4. The other factors were replaced by chemical compounds. Thus, we continue a major transition in the iPS cell field away from genes and toward chemicals.
From genes to chemicals: iPS cell field, reprogramming in transition Read More »
A paper just came out in PNAS entitled “Promotion of direct reprogramming by transformation-deficient Myc“. The main thrust of this paper is that the tumorigenic and pluripotency-related functions of Myc could be separated. It focused primarily on the lesser studied LMyc. The topic of the intertwined good (pluripotency) and bad (tumorigenicity) functions of Myc, addressed
Tumorigenicity and Pluripotency teased apart? Not yet for Myc Read More »